Results 121 to 130 of about 261,478 (313)

Programmed cell death disrupts inflammatory tumor microenvironment (TME) and promotes glioblastoma evolution

Cell Communication and Signaling
Glioblastoma (GBM) is the most common malignant brain tumor and has a dismal prognosis even under the current first-line treatment, with a 5-year survival rate less than 7%.
Tingyu Liang, Lingui Gu, Xiaoman Kang, Junlin Li, Yixuan Song, Yu Wang, Wenbin Ma   +6 more
doaj   +1 more source

Terahertz meta-biosensor for subtype detection and chemotherapy monitoring of glioma cells

Materials & Design
Rapid and precise identification of glioma subtypes can assist surgeons in quickly determining patients’ conditions and developing treatment plans. However, current methods face challenges such as high cost and limited sensitivity, thereby significantly ...
Ning Mu, Chiben Zhang, Chuanyan Yang, Kang Ma, Ying Lai, Yu Chen, Peng Chen, Hui Yang, Yue Zhao, Fei Li, Xiuwu Bian, Weiren Zhu, Hua Feng, Tunan Chen   +13 more
doaj   +1 more source

Evaluation of biomarkers in glioma by immunohistochemistry on paraffin- embedded 3D glioma neurosphere cultures

, 2019
Analysis of protein expression in glioma is relevant for several aspects in the study of its pathology. Numerous proteins have been described asbiomarkers with applications in diagnosis, prognosis, classification, state of tumor progression, and cell ...
Lowenstein, Pedro R., Núñez Aguilera, Felipe Javier, Mendez, Flor M., Garcia Fabbiani, María B., Pardo, Joaquin, Castro, María G., Edwards, Marta   +6 more
core   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

Efficacy and influencing factors of bevacizumab monotherapy and combination therapy in recurrent high-grade glioma: a twelve-year experience

BMC Neurology
Background Gliomas are the most prevalent primary malignant brain tumors in adults, with high-grade gliomas (HGGs) characterized by elevated recurrence rates, aggressiveness, and mortality.
Hai Wang, Wenlin Chen, Yixuan Song, Yaning Cao, Xiaopeng Guo, Ling Zhang, Xin Zhang, Yulu Ge, Junlin Li, Yilin Li, Xiaoman Kang, Jiahui Liu, Yijun Dong, Zihan Zhong, Shanmu Jin, Qianshu Liu, Yu Wang, Wenbin Ma   +17 more
doaj   +1 more source

Radiotherapy Enhances the Oncolytic Efficacy of the Novel Oncolytic Herpesvirus VG161 and Amplifies Its Antitumor Immunity in Breast Cancer

Advanced Science, EarlyView.
RT promotes VG161 replication in BC and its immunostimulatory transgenes expression, which is mediated by the upregulation of GADD34 and HVEM caused by RT. The combination therapy with VG161 and RT increases the abundances of tumor‐infiltrating lymphocytes and elicits potent systemic antitumor immunity, thereby effectively inhibiting local tumors and ...
Lijuan Lyu, Ming Yi, Ji Chen, Zeda Zhao, Ruocen Liao, Yingnan Wang, Shengtao Hu, Jun Ding, Ronghua Zhao, William Jia, Yinan Shen, Yongchang Wei, Kongming Wu, Zhijun Dai   +13 more
wiley   +1 more source

YB-1 dependent oncolytic adenovirus efficiently inhibits tumor growth of glioma cancer stem like cells [PDF]

, 2013
Background: The brain cancer stem cell (CSC) model describes a small subset of glioma cells as being responsible for tumor initiation, conferring therapy resistance and tumor recurrence.
Mittelbronn, Michel Guy André, Janina Seznec, Michel Mittelbronn, Jürgen Schlegel, Surowiak, Pawel, Ulrike Naumann, Klaus Mantwill, Naumann, Ulrike, Vroni Girbinger, Per Holm, Dagmar Beier, Girbinger, Vroni, Lage, Hermann, Holm, Per Sonne, Pawel Surowiak, Hermann Lage, Schlegel, Jürgen, Beier, Dagmar, Seznec, Janina, Mantwill, Klaus   +19 more
core   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

A prognostic model for overall survival in recurrent glioma patients treated with bevacizumab-containing therapy

Discover Oncology
Predictive markers and prognostic models are useful for the individualization of cancer treatment. In this study, we sought to identify clinical and molecular factors to predict overall survival in recurrent glioma patients receiving bevacizumab ...
Shanmu Jin, Wenlin Chen, Xiaopeng Guo, Hao Xing, Huiyu Yang, Qianshu Liu, Delin Liu, Kun Zhang, Hai Wang, Yu Xia, Siying Guo, Yaning Wang, Yixin Shi, Yilin Li, Yuekun Wang, Junlin Li, Jiaming Wu, Tingyu Liang, Tian Qu, Huanzhang Li, Tianrui Yang, Yu Wang, Wenbin Ma   +22 more
doaj   +1 more source