Results 61 to 70 of about 437,642 (362)

Coordinated regulation of IGF1R by HIF1α and HIF2α enhances chemoresistance in glioblastoma

Frontiers in Pharmacology
BackgroundThis study investigates whether Hypoxia-Inducible Factor 1 alpha (HIF1α) and Hypoxia-Inducible Factor 2 alpha (HIF2α) coordinately regulate insulin-like growth factor 1 receptor (IGF1R) expression, thereby influencing chemosensitivity in ...
Bin Liao, Bin Liao, Pan Wang, Sheng Gong, Lu Zhao, Lu Zhao, Jie Liu, Jie Liu, Nan Wu, Nan Wu   +9 more
doaj   +1 more source

Comprehensive RNAseq analysis reveals PIK3CD promotes glioblastoma tumorigenesis by mediating PI3K-Akt signaling pathway

Glioma, 2020
Background and Aim: Glioblastoma (GBM) is the most common and aggressive form of primary malignant brain tumors. Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta (PIK3CD), which is overexpressed in GBM, is involved in GBM ...
Zulfikar Azam, Wei Shao, Ho-keung Ng, Jing Wang, Zhong-ping Chen, Shing-shun Tony To   +5 more
doaj   +1 more source

Research progress of drug resistance mechanisms to temozolomide in glioblastoma: A narrative review

Glioma, 2022
Glioblastoma multiforme (GBM) is the most common malignant tumor in the adult central nervous system, and surgery combined with radiotherapy and chemotherapy represents the main treatment regimens.
Allen Lu
doaj   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

miR-652-5p promoter hypermethylation enhances glioblastoma malignancy through the SDC1/TGFβ2/pERBB4 complex via HIF2α-mediated regulation under hypoxia

Cancer Cell International
Background Glioblastoma multiforme (GBM) is highly malignant, and hypoxia often exacerbates its aggressiveness. The aim of this study was to explore the molecular mechanism by which miR-652-5p promoter hypermethylation augments the malignancy of ...
Pan Wang, Sheng Gong, Bin Liao, Jie Liu, Lu Zhao, Hui Yao, Nan Wu   +6 more
doaj   +1 more source

Surgical resection of glioma involving eloquent brain areas: Tumor boundary, functional boundary, and plasticity consideration

Glioma, 2020
Glioma is the most refractory intracranial tumor, and its diffuse infiltrative growth characteristics make total resection impossible in a biological sense, especially when tumors invade eloquent brain areas.
Yu Lin, Xuejun Yang
doaj   +1 more source

The Irradiated Brain Microenvironment Supports Glioma Stemness and Survival via Astrocyte-Derived Transglutaminase 2 [PDF]

, 2021
Tracy J. Berg, Carolina Marques, Vasiliki Pantazopoulou, Elinn Johansson, Kristoffer von Stedingk, David Lindgren, Pauline Jeannot, Elin J. Pietras, Tobias Bergström, Fredrik J. Swartling, Valeria Governa, Johan Bengzon, Mattias Belting, Håkan Axelson, Massimo Squatrito, Alexander Pietras   +15 more
openalex   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Tumor growth patterns in central nervous system tumors with astrocytic differentiation

Glioma, 2020
Background and Aim: Glial tumors with astrocytic differentiation are the most common primary malignant brain tumors. Hans Joachim Scherer established histological criteria based on hematoxylin and eosin (H&E) staining, which form the basis of the World ...
Emran Myumyun Lyutfi, Reneta Georgieva, George S Stoyanov, Deyan Dzhenkov   +3 more
doaj   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source