Results 51 to 60 of about 382,034 (365)

Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy

, 2011
Background: Even in the presence of oxygen, malignant cells often highly depend on glycolysis for energy generation, a phenomenon known as the Warburg effect.
Stefan Walenta, Wolfgang Mueller-Klieser, Brucker, Daniel P., Steinbach Joachim P, Rieger Johannes, Maurer, Gabriele D., Harter Patrick N, Hattingen, Elke, Walenta Stefan, Müller-Klieser, Wolfgang, Hattingen Elke, Elke Hattingen, Rieger, Johannes, Daniel P Brucker, Bähr Oliver, Harter, Patrick Nikolaus, Maurer Gabriele D, Bähr, Roy Oliver, Steinbach, Joachim Peter, Patrick N Harter, Mueller-Klieser Wolfgang, Oliver Bähr, Walenta, Stefan, Brucker Daniel P, Johannes Rieger, Gabriele D Maurer, Joachim P Steinbach   +26 more
core   +1 more source

Monoclonal antibodies against human astrocytomas and their reactivity pattern [PDF]

, 1987
The establishment of hybridomas after fusion of X63-Ag8.653 mouse myeloma cells and splenocytes from mice hyperimmunized against human astrocytomas is presented. The animals were primed with 5 × 106 chemically modified uncultured or cultured glioma cells.
Eisenmenger, Wolfgang, Schmidberger, F., Funke, I., Kurrle, R., Martin, B., Stavrou, D., Bise, K., Stocker, U., Keiditsch, E.   +8 more
core   +1 more source

Angiogenesis in gliomas.

Folia Histochemica et Cytobiologica, 2008
Brain gliomas are characterized by invasive growth and neovascularisation potential. Angiogenesis plays a major role in the progression of gliomas and its determination has a great prognostic value. The aim of the study was to assess the vascularisation of chosen brain gliomas and to estimate how it is correlated with tumour histological type ...
Elzbieta Czykier, Lech Zimnoch, Dorota Lemancewicz, Katarzyna Guzińska-Ustymowicz, Janusz Dziecioł, Agnieszka Lebelt   +5 more
openaire   +4 more sources

Initial report of a clinical trial evaluating the safety and efficiency of neoadjuvant camrelizumab and apatinib in patients with recurrent high-grade gliomas: A prospective, phase II, single-arm study

Glioma, 2022
Background and Aim: High-grade glioma is the most common malignant primary brain tumor in the central nervous system. Multiple strategies such as surgery, radiotherapy, and chemotherapy have been used, but the prognosis of patients with high-grade glioma
Fuhua Lin, Chengcheng Guo, Qunying Yang, Yinsheng Chen, Chao Ke, Ke Sai, Ji Zhang, Xiaobing Jiang, Wanming Hu, Shaoyan Xi, Jian Zhou, Depei Li, Zhihuan Zhou, Qinqin Zhao, Xi Cao, Zhong-ping Chen   +15 more
doaj   +1 more source

Vorasidenib, a dual inhibitor of mutant IDH1/2, in recurrent or progressive glioma; Results of a first-in-human Phase I trial

Clinical Cancer Research, 2021
Purpose: Lower grade gliomas (LGGs) are malignant brain tumors. Current therapy is associated with short- and long-term toxicity. Progression to higher tumor grade is associated with contrast enhancement on MRI.
I. Mellinghoff, M. Penas-Prado, K. Peters, H. Burris, E. Maher, F. Janku, G. Cote, M. I. de la Fuente, Jennifer L. Clarke, B. Ellingson, Saewon Chun, R. Young, Hua Liu, S. Choe, Min Lu, Kha N. Le, Islam Hassan, L. Steelman, S. Pandya, T. Cloughesy, P. Wen   +20 more
semanticscholar   +1 more source

O-methylguanine-DNA methyltransferase (MGMT) mRNA expression predicts outcome in malignant glioma independent of MGMT promoter methylation [PDF]

, 2011
Background: We analyzed prospectively whether MGMT (O(6)-methylguanine-DNA methyltransferase) mRNA expression gains prognostic/predictive impact independent of MGMT promoter methylation in malignant glioma patients undergoing radiotherapy with ...
Kreth Simone, Friedrich W. Kreth, Hans A Kretzschmar, Lutz Juergen, Ludwig C. Hinske, Friedrich W Kreth, Ledderose Carola, Kretzschmar, Hans A., Kreth, Friedrich-Wilhelm, Juergen Lutz, Eigenbrod, Sabina, Kreth, Simone, Tonn, Joerg C., Thon Niklas, Thon, Niklas, Eigenbrod Sabina, Joerg C Tonn, Hinske, Ludwig C., Egensperger Rupert, Kretzschmar Hans A., Carola Ledderose, Rupert Egensperger, Kreth Friedrich W., Joerg C. Tonn, Lutz, Juergen, Niklas Thon, Hans A. Kretzschmar, Kreth, Friedrich W., Egensperger, Rupert, Hinske Ludwig C., Hinske, Ludwig Christian, Ludwig C Hinske, Sabina Eigenbrod, Tonn Joerg C., Ledderose, Carola, Simone Kreth   +35 more
core   +1 more source

Angiocentric glioma: the infiltrative glioma with ependymal differentiation [PDF]

Turkish Journal of Pathology, 2013
Angiocentric glioma is an epileptogenic, infiltrative, low grade glial tumor, with ependymal and astrocytic differentiation, most commonly seen in young adults and the pediatric age group. Herein we report a case of 21-year-old male patient who presented with fever and pharmaco-resistant seizures.
Ersen, Ayca, Canda, Tulay, KALEMCİ, ORHAN, MEN, SÜLEYMAN, Yucesoy, Kemal, Canda, M. Serefettin   +5 more
openaire   +4 more sources

The relationship between expression of PD-L1 and HIF-1α in glioma cells under hypoxia

Journal of Hematology & Oncology, 2021
Hypoxia inducible factor-1α (HIF-1α) up-regulates the expression of programmed death ligand-1 (PD-L1) in some extracranial malignancies. However, whether it could increase PD-L1 expression in intracranial tumor is still unknown.
Xing-chen Ding, Liangliang Wang, Xue-dong Zhang, Junlong Xu, Pei-feng Li, H. Liang, Xianbin Zhang, Li Xie, Zihan Zhou, Jia Yang, R. Weichselbaum, Jinming Yu, M. Hu   +12 more
semanticscholar   +1 more source

Specific anti‐glioma targeted‐delivery strategy of engineered small extracellular vesicles dual‐functionalised by Angiopep‐2 and TAT peptides

Journal of Extracellular Vesicles, 2022
Glioma is one of the primary malignant brain tumours in adults, with a poor prognosis. Pharmacological reagents targeting glioma are limited to achieve the desired therapeutic effect due to the presence of blood‐brain barrier (BBB).
Zhanchi Zhu, Yuanxin Zhai, Ying Hao, Quanwei Wang, Fang Han, Wenlong Zheng, Jing Hong, Leisha Cui, W. Jin, Sancheng Ma, Lingyan Yang, G. Cheng   +11 more
semanticscholar   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source