Results 61 to 70 of about 382,034 (365)

Hypoxic glioma-derived exosomes promote M2-like macrophage polarization by enhancing autophagy induction

Cell Death and Disease, 2021
Exosomes participate in intercellular communication and glioma microenvironment modulation, but the exact mechanisms by which glioma-derived exosomes (GDEs) promote the generation of the immunosuppressive microenvironment are still unclear.
Jianye Xu, Jian Zhang, Zongpu Zhang, Zijie Gao, Yanhua Qi, W. Qiu, Z. Pan, Qindong Guo, Boyan Li, Shulin Zhao, Xiaofan Guo, Mingyu Qian, Zihang Chen, Shaobo Wang, Xiao Gao, Shouji Zhang, Huizhi Wang, Xing Guo, Ping Zhang, Rongrong Zhao, H. Xue, Gang Li   +21 more
semanticscholar   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Preclinical validation of intraoperative optical imaging in pig somatosensory cortex mapping

European Journal of Medical Research
Objectives Preserving functional brain tissue is critical in neurosurgery, especially when operating near eloquent areas such as the primary sensory cortex (PSC).
Tong Liu, Nainai Ma, Juanjuan He, Ye Wang, Feili Liu, Lei Jin, Jinsong Wu   +6 more
doaj   +1 more source

Germline predisposition to glial neoplasms in children and young adults: A narrative review

Glioma, 2021
Gliomas are the most common malignancies of the central nervous system (CNS). A significant proportion of both low- and high-grade gliomas in children, adolescents, and young adults have specific genetic events which can be traced to the germline ...
Anirban Das, Cynthia Hawkins, Uri Tabori   +2 more
doaj   +1 more source

Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma

Cancer Cell, 2017
Summary We collated data from 157 unpublished cases of pediatric high-grade glioma and diffuse intrinsic pontine glioma and 20 publicly available datasets in an integrated analysis of >1,000 cases. We identified co-segregating mutations in histone-mutant
A. Mackay, A. Burford, Diana M. Carvalho, E. Izquierdo, J. Fazal-Salom, Kathryn R. Taylor, Lynn Bjerke, M. Clarke, M. Vinci, M. Nandhabalan, Sara Temelso, S. Popov, V. Molinari, Pichai Raman, A. Waanders, Harry J Han, Saumya Gupta, L. Marshall, S. Zacharoulis, S. Vaidya, H. Mandeville, L. Bridges, A. Martin, S. Al-Sarraj, C. Chandler, H. Ng, Xingang Li, K. Mu, S. Trabelsi, D. Brahim, Alexei N. Kisljakov, Dmitry M. Konovalov, A. Moore, A. Carcaboso, M. Suñol, C. de Torres, O. Cruz, J. Mora, L. Shats, J. Stávale, L. Bidinotto, R. Reis, N. Entz-Werlé, M. Farrell, J. Cryan, D. Crimmins, J. Caird, J. Pears, Michelle Monje, M. Debily, D. Castel, J. Grill, C. Hawkins, H. Nikbakht, N. Jabado, S. Baker, S. Pfister, David T. W. Jones, M. Fouladi, A. V. von Bueren, M. Baudis, A. Resnick, Chris Jones   +62 more
semanticscholar   +1 more source

Efeito dos glicosaminoglicanos (GAGs) sobre a progressão do glioma C6: abordagens in vitro e in vivo / [PDF]

, 2001
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas.O presente estudo tem por objetivo verificar efeitos dos glicosaminoglicanos sobre a adesão in vitro do glioma C6.
Soares, Bruno Lobão
core  

Induction of selective blood-tumor barrier permeability and macromolecular transport by a biostable kinin b1 receptor agonist in a glioma rat model

, 2012
Treatment of malignant glioma with chemotherapy is limited mostly because of delivery impediment related to the blood-brain tumor barrier (BTB). B1 receptors (B1R), inducible prototypical G-protein coupled receptors (GPCR) can regulate permeability of ...
Neugebauer Witold, Audrey Fortier, Martin Savard (163526), David Fortin (163586), Tsanaclis Ana-Maria, Céléna Dubuc, Jérôme Côté (163514), Céléna Dubuc (163533), Audrey Fortier (163543), Dubuc Céléna, Gobeil, Fernand, Müller-Esterl Werner, Fortin David, Neugebauer, Witold, Werner Müller-Esterl, Gobeil Fernand, Martin Savard, Fortier, Audrey, Tsanaclis, Ana-Maria, Witold Neugebauer (163552), Fernand Gobeil, Tremblay Luc, Luc Tremblay (163561), Lepage, Martin, Veronica Bovenzi (163520), Müller-Esterl, Werner, Bovenzi Veronica, David Fortin, Jérôme Côté, Ana-Maria Tsanaclis, Martin Lepage (125474), Fernand Gobeil Jr (163594), Savard Martin, Fortier Audrey, Dubuc, Céléna, Tremblay, Luc, Lepage Martin, Côté, Jérôme, Luc Tremblay, Martin Lepage, Ana-Maria Tsanaclis (163574), Bovenzi, Veronica, Savard, Martin, Veronica Bovenzi, Côté Jérôme, Fortin, David, Werner Müller-Esterl (37090), Witold Neugebauer   +47 more
core   +1 more source

Gliomas in Families [PDF]

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 1992
ABSTRACT:This is a descriptive study of 19 families with glial tumors. Twelve were identified prospectively from 178 consecutive, unrelated adults and children with newly diagnosed gliomas seen at a regional cancer center between 01 Jan 89 and 31 Mar 91 (6.7%). There were 45 affected members (42 confirmed); 30 males, 15 females, ages 4 months-78 years (
Y, Ikizler, D J, van Meyel, D A, Ramsay, G L, Abdallah, R M, Allaster, D R, Macdonald, W K, Cavenee, J G, Cairncross   +7 more
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A Mendelian randomization study: causal relationship between immune cells and the risks of social phobia, specific phobia, and agoraphobia

BMC Psychiatry
Background Although phobia is a common psychiatric disorder, the underlying biological mechanisms have not been fully elucidated. Complex immune-brain interactions that affect neural development, survival, and function may have causal and therapeutic ...
Jun-Neng Wang, Dong-Hu Yu, Zhi-Yu Li, Ling-Yue Kong, Nan-Hao Li, You-Xian Wu, Tian-Qing Wang, Ze-Fen Wang, Zhi-Qiang Li   +8 more
doaj   +1 more source