Results 61 to 70 of about 261,478 (313)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Temozolomide promotes glioblastoma stemness expression through senescence-associated reprogramming via HIF1α/HIF2α regulation

Cell Death and Disease
A critical challenge in glioblastoma multiforme (GBM) treatment is that tumors recurring after temozolomide (TMZ) therapy become more malignant, exhibiting increased invasiveness and stemness compared to the primary tumor.
Pan Wang, Bin Liao, Sheng Gong, HaiYan Guo, Lu Zhao, Jie Liu, Nan Wu   +6 more
doaj   +1 more source

Progress on TTFields combined with other therapies for glioblastoma treatment: A narrative review

Glioma, 2022
Glioma is the most common primary malignant tumor in the skull, and the current treatment remains a combination of surgery, radiotherapy (RT), and chemotherapy. Radiation therapy plays an important role in the treatment of glioma, and currently, surgical
Yong Cao, Haibin Wu, Bin Tang, Meihua Li, Yilv Wan, Jian Duan, Jiang Xu   +6 more
doaj   +1 more source

Crucial roles of exosomes secreted from ganglioside GD3/GD2-positive glioma cells in enhancement of the malignant phenotypes and signals of GD3/GD2-negative glioma cells [PDF]

Neuroectoderm-derived tumors characteristically express gangliosides such as GD3 and GD2. Many studies have reported that gangliosides GD3/GD2 enhance malignant phenotypes of cancers.
Kambe, Mariko, Ohkawa, Yuki, Furukawa, Keiko, Mizutani, Momoka, Furukawa, Koichi, Hashimoto, Noboru, Kawamoto, Yoshiyuki, Tajima, Orie, Hasnat, Mohammad Abul, Bhuiyan, Robiul H., Yesmin, Farhana, Kaneko, Kei, Tsuchida, Akiko, Ohmi, Yuhsuke   +13 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

GLIOMA OF THE BUTTOCK

Annals of Surgery, 1919
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openaire   +3 more sources

Effect of PPARα Ligand on TNFα -Dependent Expression of EGF Receptor in Human Glioma Cell Line

, 2002
2002-12In glioma cells, tumor necrosis factor alpha (TNFα) was reported to increase the number of epidermal growth factor receptor (EGFR) that mediates EGF-dependent cell proliferation.
KAMBE, Fukushi, KATO, Mihoko, NAGAYA, Takashi, SAITO, Kiyoshi, YOSHIDA, Jun, SEO, Hisao, WAKABAYASHI, Kenichi   +6 more
core   +1 more source

PUMA mediated afatinib-induced apoptosis in glioma cells

, 2021
Introduction Afatinib exhibits a tumor-inhibiting effect in different cancers by inducing apoptosis; however, its pro-apoptosis role in glioma cells is still not fully understood. Material and methods In the current study, two glioma cell lines (U373-MG
Xinyue Sun, Rongzhong Lu, Rong Wang, Yaping Ma   +3 more
core   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source