Neuroprotective Effects of RNS60 in TDP‐43 Pathology‐Associated Amyotrophic Lateral Sclerosis
Muscle &Nerve, Volume 74, Issue 2, Page 463-473, August 2026.ABSTRACT Introduction TDP‐43 pathology is broadly observed in the cerebral cortex of patients with amyotrophic lateral sclerosis (ALS). RNS60, an experimental treatment for acute ischemic stroke and ALS, enhanced mitochondrial biogenesis and function in other preclinical models.
Danny R. Vesevick +4 more
wiley +1 more source
Synaptic alterations are preceding the axonal loss in optic atrophy of Wolfram syndrome mouse model. [PDF]
Front NeurosciGurram V, An W, Bimal S, Urano F.
europepmc +1 more source
High‐Resolution Diffusion Kurtosis Imaging of Hippocampus Subfields Across the Healthy Lifespan
NMR in Biomedicine, Volume 39, Issue 8, August 2026.Developmental and aging changes were examined in the hippocampus using 1 mm isotropic diffusion kurtosis imaging in 363 participants aged 5–90 years. HippUnfold enabled automated subfield segmentation and unfolded hippocampal maps. Whole‐hippocampus showed distinct lifespan trajectories: volume, quadratic; MD, negative Gamma Variate; FA, positive Gamma
Pablo Stack‐Sanchez +3 more
wiley +1 more source
Persistent Pathological Yawning due to Neuromyelitis Optica Spectrum Disorder. [PDF]
Ann Indian Acad NeurolSaroja AO, Naik KR.
europepmc +1 more source
Chemokines in Alzheimer's Disease: Early Defence, Late Damage and the Impact of Sex and Infection
Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 2, August 2026.ABSTRACT Chemokines constitute a versatile signalling network maintaining homeostasis and glia–neuron communication in the healthy brain but become progressively dysregulated during aging and Alzheimer's disease (AD). This review examines how chemokine systems transition from tightly regulated homeostatic signals to drivers of chronic neuroinflammation
Blanca I. Aldana, Kristine Freude
wiley +1 more source
Central Pontine Myelinolysis and Hypokalemic Paralysis as Initial Manifestations of Primary Sjögren's Syndrome: A Rare Electrolyte-Mediated Neurological Presentation. [PDF]
CureusSrinivas R, Gk P.
europepmc +1 more source
Neuropathology and Applied Neurobiology, Volume 52, Issue 4, August 2026.We report an autopsy case of frontotemporal lobar degeneration (FTLD)‐TDP type C with severe striatal involvement and annexin A11‐ and phosphorylated TDP‐43‐positive glial cytoplasmic inclusions. The patient developed progressive asymmetric rigidity accompanied by marked striatal atrophy and showed both upper and lower motor neuron involvement.
Akiko Uchino +7 more
wiley +1 more source
Neuroprotective effects of curcumin, memantine, and caffeic acid in a Rat model of cerebral ischemia-reperfusion injury. [PDF]
Front PharmacolCakir CO +5 more
europepmc +1 more source
FMRP‐Mediated Proteasome Regulation: A Novel Mechanism in ALS Pathology
The FASEB Journal, Volume 40, Issue 13, 15 July 2026.Schematic model of TDP‐43/TNKS‐mediated proteasome regulation in WT, FMRP‐depleted, and TDP‐43A315T‐Tg ALS neurons. In WT neurons, cytoplasmic TDP‐43 partially sequesters TNKS, maintaining balanced PI31 ribosylation and proteasome activity. FMRP depletion promotes nuclear translocation of TDP‐43, enhances TNKS/PI31 interaction, and increases axonal ...
Pritha Majumder +5 more
wiley +1 more source
Cervical flexion-induced myelopathy (Hirayama disease): A radiology case report. [PDF]
Radiol Case RepUlaganathan B +3 more
europepmc +1 more source