Results 221 to 230 of about 79,800 (306)

Exosome Proteomics of SOD1D90A Mutation Suggest Early Disease Mechanisms, and FN1 as a Biomarker

Annals of Clinical and Translational Neurology, Volume 13, Issue 1, Page 131-143, January 2026.
ABSTRACT Amyotrophic lateral sclerosis (ALS) is a neuromuscular disease. Super oxide dismutase 1 (SOD1) gene mutations cause ALS, and the D90A mutation is associated with primarily upper motor neuron (UMN) loss. Objective Our goal is to reveal the early cellular events in ALS pathology and identify potential pharmacokinetic biomarkers, using well ...
Mukesh Gautam, Ali Laith, Aslihan Gunel, Melda Yilmaz, Nazli Basak, Halil Idrisoglu, P. Hande Ozdinler   +6 more
wiley   +1 more source

Chronic granulomatous herpes simplex encephalitis in a child with digeorge syndrome- expanding the spectrum of herpes-associated neurological disease. [PDF]

BMC Infect Dis
Kewalramani DA, Kanagavel Y, Krishnaswamy V, Ravichandran L, Cruz LD, Ramanan PV, Mohan R, Manokaran DRK.   +7 more
europepmc   +1 more source

Neuroimmune Microenvironment Reprogramming via Immuno‐piezoelectric Transducers for Synergistic Stem Cell Therapy in Traumatic Brain Injury

Advanced Materials, Volume 38, Issue 2, 8 January 2026.
A novel immuno‐piezoelectric transducer is innovatively developed. This device promotes neural stem cell (NSC) differentiation and maturation via ultrasound‐induced electrical stimulation and it amplifies the therapeutic efficacy of NSC in traumatic brain injury (TBI) by modulating the immune microenvironment. This piezoelectric transducer with “immune‐
Linlin Liang, Xin Li, Kai Hu, Pingqiang Cai, Jianwu Wang, Jing Yu, Shasha Wang, Yuwei Zhao, Changgeng Xu, Siwei Li, Hong Liu, Changyong Wang, Jin Zhou   +12 more
wiley   +1 more source

Eye-Targeted A20 Gene Therapy Alleviates Ischemic Retinopathy by Reducing Pathologic Neovascularization, Gliosis, and Neuronal Apoptosis. [PDF]

FASEB J
Essayagh S, Aridi T, Turunen T, Choi L, Adam H, Patel N, Scali ST, Fisher MD, Skaf K, Csizmadia E, Brennan P, Sadek A, Skaf J, Zhan M, Hansen E, Shamloo M, DeStefino NR, Clermont AC, Angolano C, Ferran C.   +19 more
europepmc   +1 more source

Lithium‐Charged Gold Nanoparticles: A New Powerful Tool for Lithium Delivery and Modulation of Glycogen Synthase Kinase 3 Activity

Advanced Materials, Volume 38, Issue 3, 13 January 2026.
This study introduces glutathione‐stabilized gold nanoparticles for targeted lithium delivery (LiG‐AuNPs), enabling the controlled modulation of Glycogen Synthase Kinase‐3 (GSK‐3β). These non‐toxic, 2‐nm particles release lithium intracellularly, effectively inhibiting GSK‐3β in the brain without significant plasma lithium alterations.
Antonio Buonerba, Giulia Puliatti, Domenica Donatella Li Puma, Bruno Bandiera, Beatrice Cannata, Maria Elena Marcocci, Nicolina Castagno, Irene Contento, Salvatore Impemba, Mariarosa Scognamiglio, Rocco Di Girolamo, Vincenzo Naddeo, Patrizia Canton, Carmine Capacchione, Laura Sposito, Martina Albini, Francesco Pastore, Silvia Baroni, Alfonso Grassi, Claudio Grassi, Roberto Piacentini   +20 more
wiley   +1 more source

Retinal biomarkers for early Alzheimer's detection: a systematic review of optical coherence tomography (OCT) findings. [PDF]

BMJ Open Ophthalmol
Lepoittevin M, Greig J, Erol O, Benani A, Bauvin P, Azzolini C, Donati S, Dubois B, Boscher C, Bodard S.   +9 more
europepmc   +1 more source

Microfabricated Neural Biosensors for Detection of Neurotransmitters, Biomarkers, and Small Molecules: Emerging Trends on Self‐Sustained Systems and Energy Harvesting

Advanced Sensor Research, Volume 5, Issue 1, January 2026.
This paper reviews the state of the art and recent developments in thin‐film biosensors for the detection of neurotransmitters, small molecules, and biomarkers within flexible, implantable bioelectronic systems. It covers the main sensing modalities, including electrochemical, plasmonic, acoustic, and magnetic, alongside their materials, transduction ...
Massimo Mariello
wiley   +1 more source

Gamma-interferon promotes proliferation of adult human astrocytes in vitro and reactive gliosis in the adult mouse brain in vivo.

, 1991
V. Wee Yong, Robert Moumdjian, Fiona P. Yong, Theodora C.J. Ruijs, Mark S. Freedman, Neil R. Cashman, Jack P. Antel   +6 more
openalex   +2 more sources

Elevated Apolipoprotein E Expression in Hippocampal Microglia Drives Temporal Lobe Epilepsy Progression

Advanced Science, Volume 13, Issue 2, 9 January 2026.
In temporal lobe epilepsy, hippocampal APOE is markedly upregulated predominantly in microglia. APOE overexpression in microglia drives TLR4 and cGAS/STING‐dependent neuroinflammation, engages bidirectional crosstalk with neurons and astrocytes, increases neuronal excitability, and perturbs hippocampal lipid metabolism. These findings suggest that APOE‐
Jianwei Shi, Zesheng Li, Xin Sun, Yanfeng Yang, Yumin Luo, Ziang Song, Hengxin Dong, Lei Jin, Jing Xie, Yongzhi Shan, Guoguang Zhao   +10 more
wiley   +1 more source

A fixed brain seeded amplification assay to complement neuropathological prion disease diagnosis. [PDF]

J Neuropathol Exp Neurol
Lewis V, Ellett L, Lei E, Stehmann C, Birchall I, Senesi M, McLean C, Collins SJ.   +7 more
europepmc   +1 more source