Results 91 to 100 of about 5,259,770 (378)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Dynamics of a damped quintic wave equation with time-dependent coefficients
AIMS MathematicsWe present a comprehensive investigation of the long-term dynamics generated by a semilinear wave equation with time-dependent coefficients and quintic nonlinearity on a bounded domain subject to Dirichlet boundary conditions.
Feng Zhou +3 more
doaj +1 more source
State Differentiation by Transient Truncation in Coupled Threshold Dynamics
, 2006 Dynamics with a threshold input--output relation commonly exist in gene, signal-transduction, and neural networks. Coupled dynamical systems of such threshold elements are investigated, in an effort to find differentiation of elements induced by the ...
B. Alberts +11 more
core +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Global attractors for a class of degenerate diffusion equations
Electronic Journal of Differential Equations, 2003 In this paper we give two existence results for a class of degenerate diffusion equations with p-Laplacian. One is on a unique global strong solution, and the other is on a global attractor.
Shingo Takeuchi, Tomomi Yokota
doaj
Anomalous diffusion in polymers: long-time behaviour
, 2009 We study the Dirichlet boundary value problem for viscoelastic diffusion in polymers. We show that its weak solutions generate a dissipative semiflow.
AV Babin +28 more
core +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Global attractor and finite dimensionality for a class of dissipative equations of BBM's type
Electronic Journal of Differential Equations, 1998 In this work we study the Cauchy problem for a class of nonlinear dissipative equations of Benjamin-Bona-Mahony's type. We discuss the existence of a global attractor and estimate its Hausdorff and fractal dimensions.
M.A. Astaburuaga +3 more
doaj
Asymptotic behavior for second order lattice dynamical systems
Discrete Dynamics in Nature and Society, 2001 We consider the existence of the global attractor for a second order lattice dynamical systems.
Shengfan Zhou
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source