Results 91 to 100 of about 54,142 (287)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Global dynamics of a fourth-order parabolic equation describing crystal surface growth

open access: yesNonlinear Analysis, 2019
In this paper, we study the global dynamics for the solution semiflow of a fourth-order parabolic equation describing crystal surface growth. We show that the equation has a global attractor in H4per(Ω) when the initial value belongs to H1per(Ω).
Ning Duan, Xianyun Xu
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Existence and regularity of a global attractor for doubly nonlinear parabolic equations

open access: yesElectronic Journal of Differential Equations, 2002
In this paper we consider a doubly nonlinear parabolic partial differential equation $$ frac{partial eta (u)}{partial t}-Delta _{p}u+f(x,t,u)=0 quad hbox{in }Omega imesmathbb{R}^{+}, $$ with Dirichlet boundary condition and initial data given.
Abderrahmane El Hachimi, Hamid El Ouardi
doaj  

Time-Dependent Global Attractor for a Class of Nonclassical Parabolic Equations

open access: yesJournal of Applied Mathematics, 2014
Based on the recent theory of time-dependent global attractors in the works of Conti et al. (2013) and di Plinio et al. (2011), we prove the existence of time-dependent global attractors as well as the regularity of the time-dependent global attractor ...
Fang-hong Zhang
doaj   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

open access: yesFEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava   +3 more
wiley   +1 more source

Large diffusivity finite-dimensional asymptotic behaviour of a semilinear wave equation

open access: yesJournal of Applied Mathematics, 2003
We study the effects of large diffusivity in all parts of the domain in a linearly damped wave equation subject to standard zero Robin-type boundary conditions.
Robert Willie
doaj   +1 more source

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