Results 51 to 60 of about 6,420 (267)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

On the strongly damped wave equation and the heat equation with mixed boundary conditions

open access: yesAbstract and Applied Analysis, 2000
We study two one-dimensional equations: the strongly damped wave equation and the heat equation, both with mixed boundary conditions. We prove the existence of global strong solutions and the existence of compact global attractors for these equations in ...
Aloisio F. Neves
doaj   +1 more source

Multistability in Large Scale Models of Brain Activity.

open access: yesPLoS Computational Biology, 2015
Noise driven exploration of a brain network's dynamic repertoire has been hypothesized to be causally involved in cognitive function, aging and neurodegeneration.
Mathieu Golos   +2 more
doaj   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

open access: yesFEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli   +9 more
wiley   +1 more source

Upper semicontinuity of attractors of non-autonomous dynamical systems for small perturbations

open access: yesElectronic Journal of Differential Equations, 2002
We study the problem of upper semicontinuity of compact global attractors of non-autonomous dynamical systems for small perturbations. For the general nonautonomous dynamical systems, we give the conditions of upper semicontinuity of attractors for small
David N. Cheban
doaj  

Compact Global Chaotic Attractors of Discrete Control Systems

open access: yesNonautonomous Dynamical Systems, 2014
The paper is dedicated to the study of the problem of existence of compact global chaotic attractors of discrete control systems and to the description of its structure. We consider so called switched systems with discrete time xn+1 = fv(n)(xn), where v:
Cheban David
doaj   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

open access: yesFEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava   +3 more
wiley   +1 more source

Cross diffusion systems on n spatial dimensional domains

open access: yesElectronic Journal of Differential Equations, 2003
We show that there exists a global attractor for a triangular cross diffusion system with Lotka-Volterra reaction given on a two dimensional domain.
Dung Le
doaj  

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