Results 61 to 70 of about 4,951,195 (308)

Инвариантные многообразия и глобальный аттрактор обобщенного нелокального уравнения Гинзбурга-Ландау в случае однородных краевых условий Дирихле

open access: yesVestnik KRAUNC: Fiziko-Matematičeskie Nauki, 2022
Рассматриваются два варианта обобщенного нелокального уравнения Гинзбурга-Ландау. Оба эти варианта изучаются вместе с однородными краевыми условиями Дирихле. Для соответствующих начально-краевых задач показано существование решений при всех положительных
Куликов, А.Н.   +1 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

open access: yesFEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Simplicial Models for the Global Dynamics of Attractors

open access: yesJournal of Differential Equations, 2000
The author considers a flow \(\phi\) on a compact metric space \(\mathcal{A}\) which has a Morse decomposition \(\{S_p\}_{p\in P}\) indexed by the partially ordered set \((P,
openaire   +1 more source

Robust exponential attractors for a parabolic–hyperbolic phase-field system

open access: yesBoundary Value Problems, 2018
In this paper, we construct a robust family of exponential attractors for a parabolic–hyperbolic phase-field system (PHPFS), which describes phase separation in material sciences, e.g., melting and solidification.
Cyril D. Enyi
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

On global attractors of the 3D Navier–Stokes equations

open access: yesJournal of Differential Equations, 2006
In view of the possibility that the 3D Navier-Stokes equations (NSE) might not always have regular solutions, we introduce an abstract framework for studying the asymptotic behavior of multi-valued dissipative evolutionary systems with respect to two topologies--weak and strong.
Cheskidov, A., Foias, C.
openaire   +2 more sources

Bifurcations of attractors in 3D diffeomorphisms : a study in experimental mathematics [PDF]

open access: yes, 2003
The research presented in this PhD thesis within the framework of nonlinear deterministic dynamical systems depending on parameters. The work is divided into four Chapters, where the first is a general introduction to the other three.
Vitolo, Renato,, Vitolo, Renato
core   +9 more sources

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