Results 51 to 60 of about 43,348 (288)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Informational Structures and Informational Fields as a Prototype for the Description of Postulates of the Integrated Information Theory

Entropy, 2019
Informational Structures (IS) and Informational Fields (IF) have been recently introduced to deal with a continuous dynamical systems-based approach to Integrated Information Theory (IIT). IS and IF contain all the geometrical and topological constraints
Piotr Kalita, José A. Langa, Fernando Soler-Toscano   +2 more
doaj   +1 more source

Optimum PID Control of Multi-wing Attractors in A Family of Lorenz-like Chaotic Systems

, 2012
Multi-wing chaotic attractors are highly complex nonlinear dynamical systems with higher number of index-2 equilibrium points. Due to the presence of several equilibrium points, randomness of the state time series for these multi-wing chaotic systems is ...
Acharya, Anish, Das, Saptarshi, Pan, Indranil   +2 more
core   +1 more source

Intrinsic strong shape of global attractors

Filomat, 2022
We present a proof of the strong shape theorem for global attractors in compact metric spaces using the intrinsic approach to strong shape from [18] which combines continuity over a covering and the corresponding homotopies of second order.
Nikita Shekutkovski, Martin Shoptrajanov
openaire   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Trajectory and Global Attractors for the Kelvin–Voigt Model Taking into Account Memory along Fluid Trajectories

Mathematics
This article is devoted to the study of the existence of trajectory and global attractors in the Kelvin–Voigt fluid model, taking into account memory along the trajectories of fluid motion.
Mikhail Turbin, Anastasiia Ustiuzhaninova   +1 more
doaj   +1 more source

Uniform attractors for vanishing viscosity approximations of non-autonomous complex flows

Journal of Optimization, Differential Equations and Their Applications, 2018
In this paper we prove the existence of uniform global attractors in the strong topology of the phase space for semiflows generated by vanishing viscosity approximations of some class of non-autonomous complex fluids.
Nataliia V. Gorban, Oleksiy V. Kapustyan, Pavlo O. Kasyanov, Olha V. Khomenko, Liliia S. Paliichuk, Jose Valero, Michael Z. Zgurovsky   +6 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source