Objective This study assessed sarilumab in treating patients with polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods This phase 2b, open‐label study (NCT02776735) consisted of three sequential parts (each with a core‐treatment and extension‐phase). During part 1, three doses were assessed in two weight groups (Group A/B: ≥30–60 kg/≥10–<
Fabrizio De Benedetti +19 more
wiley +1 more source
Modelling the dynamically consistent numerical methods for COVID-19 disease with cost effectiveness strategies. [PDF]
Li S +5 more
europepmc +1 more source
Global boundedness of an N-D chemotactic tumor immune evasion system [PDF]
Kaiqiang Li, Yingying Li, Jiashan Zheng
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A Q‐Learning Algorithm to Solve the Two‐Player Zero‐Sum Game Problem for Nonlinear Systems
A Q‐learning algorithm to solve the two‐player zero‐sum game problem for nonlinear systems. ABSTRACT This paper deals with the two‐player zero‐sum game problem, which is a bounded L2$$ {L}_2 $$‐gain robust control problem. Finding an analytical solution to the complex Hamilton‐Jacobi‐Issacs (HJI) equation is a challenging task.
Afreen Islam +2 more
wiley +1 more source
Mathematical modeling and analysis for the transmission dynamics of wheat yellow rust disease. [PDF]
Fantaye AK, Dawed MY, Mekonen KG.
europepmc +1 more source
Global weak solution and boundedness in a three-dimensional competing chemotaxis
Hua Zhong, Chunlai Mu, Ke Lin
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This paper proposes two projector‐based Hopfield neural network (HNN) estimators for online, constrained parameter estimation under time‐varying data, additive disturbances, and slowly drifting physical parameters. The first is a constraint‐aware HNN that enforces linear equalities and inequalities (via slack neurons) and continuously tracks the ...
Miguel Pedro Silva
wiley +1 more source
Modeling gonorrhea and HIV coinfection with predictive analytics for disability and mortality risks. [PDF]
Ramzan Y +5 more
europepmc +1 more source
Global boundedness of a three-species spatial intraguild predation model with alarm-taxis
Pengfei Luo, Yun Zhang, Lü Xu
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Global existence and uniform boundedness of smooth solutions to a parabolic-parabolic chemotaxis system with nonlinear diffusion [PDF]
Li Xie
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