Results 61 to 70 of about 5,184,143 (243)

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Boundedness and finite-time blow-up for the chemotaxis system with indirect signal production and flux limitation

Advances in Nonlinear Analysis
In this work, we consider a flux-limited chemotaxis model with indirect signal production and nonlinear diffusion,ut=∇⋅(D(u)∇u)−∇⋅(uf(|∇v|2)∇v)−k1u+k2w,x∈Ω,t>0,0=Δv−μ(t)+w,x∈Ω,t>0,wt=Δw−λ1w+λ2u,x∈Ω,t>0 $$\begin{cases}_{t}=\nabla \cdot \left(D\left(u ...
Tu Xinyu, Mu Chunlai, Minghua Zhang
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Stochastically Ultimate Boundedness and Global Attraction of Positive Solution for a Stochastic Competitive System [PDF]

, 2014
A stochastic competitive system is investigated. We first show that the positive solution of the above system does not explode to infinity in a finite time, and the existence and uniqueness of positive solution are discussed. Later, sufficient conditions
Zhijun Liu, Shengliang Guo, Huili Xiang
core   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

A finite element approach to the Keller–Segel Chemotaxis system with impact of nonlocal diffusion

Boundary Value Problems
This paper presents the investigation of a boundedness solution for a Keller–Segel chemotaxis (KSC) system with nonlocal diffusion. In order to achieve boundedness, we derive the necessary and sufficient condition based on the assumption of ensuring a ...
A. Baskar, V. Parthiban
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Global solutions and uniform boundedness of attractive/repulsive LV competition systems

Advances in Difference Equations, 2018
In this paper, we study global solutions to the following strongly coupled systems: {ut=∇⋅(D1∇u−χu∇v)+(a1−b1u−c1v)u,x∈Ω,t>0,0=D2Δv+(a2−b2u−c2v)v,x∈Ω,t>0, $$\textstyle\begin{cases} u_{t}=\nabla\cdot(D_{1} \nabla u -\chi u \nabla v)+(a_{1}-b_{1}u-c_{1}v)u,\
Yuanyuan Zhang
doaj   +1 more source

Stability analysis for a rational difference equation

Arab Journal of Basic and Applied Sciences, 2020
Most qualitative behaviours of difference equations are rapidly investigated nowadays. This can be attributed to the fact that it is often sophisticated to construct the exact solutions of most difference equations. This article is written to analyse the
M. B. Almatrafi, Marwa M. Alzubaidi
doaj   +1 more source