Results 71 to 80 of about 3,182 (259)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Global solutions and uniform boundedness of attractive/repulsive LV competition systems

Advances in Difference Equations, 2018
In this paper, we study global solutions to the following strongly coupled systems: {ut=∇⋅(D1∇u−χu∇v)+(a1−b1u−c1v)u,x∈Ω,t>0,0=D2Δv+(a2−b2u−c2v)v,x∈Ω,t>0, $$\textstyle\begin{cases} u_{t}=\nabla\cdot(D_{1} \nabla u -\chi u \nabla v)+(a_{1}-b_{1}u-c_{1}v)u,\
Yuanyuan Zhang
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Global boundedness for weak solutions of a class of time-fractional reaction-diffusion equations

四川大学学报. 自然科学版
The aim of this paper is to study in depth the global boundedness characterization of the weak solutions of fractional reaction-diffusion equations with respect to time and to compare them with traditional nonlocal reaction-diffusion models.
ZHAN Hui, GAO Fei
doaj  

A finite element approach to the Keller–Segel Chemotaxis system with impact of nonlocal diffusion

Boundary Value Problems
This paper presents the investigation of a boundedness solution for a Keller–Segel chemotaxis (KSC) system with nonlocal diffusion. In order to achieve boundedness, we derive the necessary and sufficient condition based on the assumption of ensuring a ...
A. Baskar, V. Parthiban
doaj   +1 more source

Global Attractivity and Periodic Character of Difference Equation of Order Four

Discrete Dynamics in Nature and Society, 2012
We investigate the global convergence result, boundedness, and periodicity of solutions of the recursive sequence , where the parameters , andare positive real numbers and the initial conditions , and are positive real numbers.
M. A. Obaid, E. M. Elsayed, M. M. El-Dessoky   +2 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Regularity and Qualitative Study of Parabolic Physical Ginzburg–Landau Equations in Variable Exponent Herz Spaces via Fractional Bessel–Riesz Operators

Fractal and Fractional
In this article, we investigate the regularization and qualitative properties of parabolic Ginzburg–Landau equations in variable exponent Herz spaces. These spaces capture both local and global behavior, providing a natural framework for our analysis. We
Waqar Afzal, Mesfer H. Alqahtani, Mujahid Abbas, Daniel Breaz   +3 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source