Results 71 to 80 of about 2,928 (263)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Global Behavior for a Diffusive Predator-Prey Model with Stage Structure and Nonlinear Density Restriction-II: The Case in ℝ1

Boundary Value Problems, 2009
A Holling type III predator-prey model with self- and cross-population pressure is considered. Using the energy estimate and Gagliardo-Nirenberg-type inequalities, the existence and uniform boundedness of global solutions to the model are dicussed.
Shengmao Fu, Ling Guo, Rui Zhang
doaj   +1 more source

Qualitative Properties of Difference Equation of Order Six

Mathematics, 2016
In this paper we study the qualitative properties and the periodic nature of the solutions of the difference equation x n + 1 = α x n - 2 + β x n - 2 2 γ x n - 2 + δ x n - 5 , n = 0 , 1 , . . .
Abdul Khaliq, E.M. Elsayed
doaj   +1 more source

Stability, Neimark–Sacker Bifurcation, and Approximation of the Invariant Curve of Certain Homogeneous Second-Order Fractional Difference Equation

Discrete Dynamics in Nature and Society, 2020
We investigate the local and global character of the unique equilibrium point and boundedness of the solutions of certain homogeneous fractional difference equation with quadratic terms.
Mirela Garić-Demirović, Samra Moranjkić, Mehmed Nurkanović, Zehra Nurkanović   +3 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Regularity and Qualitative Study of Parabolic Physical Ginzburg–Landau Equations in Variable Exponent Herz Spaces via Fractional Bessel–Riesz Operators

Fractal and Fractional
In this article, we investigate the regularization and qualitative properties of parabolic Ginzburg–Landau equations in variable exponent Herz spaces. These spaces capture both local and global behavior, providing a natural framework for our analysis. We
Waqar Afzal, Mesfer H. Alqahtani, Mujahid Abbas, Daniel Breaz   +3 more
doaj   +1 more source

Existence, boundedness and integrability of global solutions to delay integro-differential equations of second order

Journal of Taibah University for Science, 2020
The paper deals with the problems of the global existence, boundedness and integrability, and solutions of an integro-differential equation (IDE) of second order with n-constant retardations.
Sizar Abid Mohammed
doaj   +1 more source

On the Boundedness of Global Solutions of Abstract Semilinear Parabolic Equations

Journal of Mathematical Analysis and Applications, 1997
Let \(X\) be a Banach space, \(A:X\supset \text{dom}(A)\to X\) be the generator of an analytic semigroup, \(Y\) be an energy space associated with \(A\) and \(F:Y\to X\) be locally Lipschitz. The authors establish sufficient conditions for the boundedness of global solutions of \[ \dot u+Au=Fu \] in a setting which is motivated by the parabolic initial-
Fila, Marek, Levine, Howard A.
openaire   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source