Results 101 to 110 of about 6,655,877 (292)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Global Demographic Change: Dimensions and Economic Significance [PDF]

Transitions from high mortality and fertility to low mortality and fertility can be beneficial to economies as large baby boom cohorts enter the workforce and save for retirement, while rising longevity has perhaps increased both the incentive to invest ...
David Canning, David E. Bloom
core  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Traceable and Scalable Food Balance Sheets from Agricultural Commodity Supply and Utilization Accounts (2010–2022)

Scientific Data
The Food Balance Sheets (FBS), compiled by the Food and Agriculture Organization (FAO), serve as a cornerstone dataset for studies on agricultural development, food security, and dietary health, providing a broad overview of global and regional food ...
Xin Zhao, Maksym Chepeliev, Neus Escobar, Matthew T. Binsted, Pralit Patel, Page Kyle, Marshall A. Wise   +6 more
doaj   +1 more source

Prediction of ozone effects on net ecosystem production of Norway spruce forest

iForest - Biogeosciences and Forestry, 2018
Future ground-level concentrations of phytotoxic ozone are projected to grow in the Northern Hemisphere, at a rate depending on emission scenarios. We explored the likely changes in net ecosystem production (NEP) due to the increasing concentration of ...
Jurán S, Edwards-Jonášová M, Cudlín P, Zapletal M, Šigut L, Grace J, Urban O   +6 more
doaj   +1 more source

Analysis of Climate Policy Targets under Uncertainty [PDF]

, 2009
and PDF report are also available on the MIT Joint Program on the Science and Policy of Global Change website (http://globalchange.mit.edu/).Although policymaking in response to the climate change is essentially a challenge of risk management, most ...
Forest, Chris Eliot, Jacoby, Henry D., Kicklighter, David W., Melillo, Jerry M., Paltsev, Sergey, Prinn, Ronald G., Reilly, John M., Sarofim, Marcus C., Schlosser, C. Adam, Sokolov, Andrei P., Wang, Chien, Webster, Mort D.   +11 more
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Gaming the unknown: learning to differentiate and respond to uncertainty through a serious game

npj Climate Action
Effective climate adaptation planning requires understanding various sources and types of uncertainty. We investigated how a serious game can improve participants’ understanding of uncertainty in adaptation decision-making.
Wout Jan-Willem Sommerauer, Bregje van der Bolt, Saskia Werners, Wouter Julius Smolenaars, Marlies van Ree, Fulco Ludwig   +5 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Simulating county‐level crop yields in the Conterminous United States using the Community Land Model: The effects of optimizing irrigation and fertilization

Journal of Advances in Modeling Earth Systems, 2016
In this study, we applied version 4.5 of the Community Land Model (CLM) at a 0.125° resolution to provide the first county‐scale model validation for simulating crop yields over the Conterminous United States (CONUS).
Guoyong Leng, Xuesong Zhang, Maoyi Huang, Qichun Yang, Rashid Rafique, Ghassem R. Asrar, L. Ruby Leung   +6 more
doaj   +1 more source