Results 221 to 230 of about 6,711,226 (342)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

1.2 million years of climate change, globally and in the Mediterranean

, 2015
T. Konijnendijk
openalex   +1 more source

Survival and aerobic performance of the northern shrimp are threatened by exposure to combined ocean global change drivers. [PDF]

Conserv Physiol
Guscelli E, Chabot D, Noisette F, Blier PU, Chemel M, Calosi P.   +5 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Resistance of the cold-water coral Dendrophyllia cornigera to single and combined global change stressors. [PDF]

Sci Rep
Gutiérrez-Zárate C, Gori A, Veiga A, Álvarez M, González-Pola C, Rakka M, Movilla J, Beck KK, Atienza EMS, Acerbi R, Orejas C.   +10 more
europepmc   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Author Correction: Public support for carbon pricing policies and revenue recycling options: a systematic review and meta-analysis of the survey literature

npj Climate Action
Farah Mohammadzadeh Valencia, Cornelia Mohren, Anjali Ramakrishnan, Marlene Merchert, Jan C. Minx, Jan Christoph Steckel   +5 more
doaj   +1 more source

Editorial: Vaccine-preventable diseases in times of climate change, economic crisis, and pandemic preparedness — a call for new approaches and global equity [PDF]

Andrea Haselbeck, Kerstin Kling
openalex   +1 more source

Evolutionary ecophysiology in extreme environments under a global change scenario. [PDF]

Conserv Physiol
Burraco P, Hawkes L, Pilakouta N, Angelier F, Brans KI, Orizaola G.   +5 more
europepmc   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source