Results 71 to 80 of about 6,655,877 (292)

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Global Climate Change Impacts on Crop Production in Hungary [PDF]

, 2007
Global climate change is one of the major issues today. There is a continuous rise in temperature escorted by the increasing frequencies of weather anomalies.
Birkás, Márta, Jolánkai, Márton
core  

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Interhemispheric Monsoon Response to Bipolar Forcing During Heinrich Stadial 4

Geophysical Research Letters
Heinrich Stadial 4 (HS4) the most prominent iceberg collapse event of the Last Glacial and a key example for studying millennial‐scale events. Based on an improved chronological, we present high‐resolution, annually laminated speleothem record from ...
Rui Zhang, Haiwei Zhang, Christoph Spötl, Xiyu Dong, Carlos Pérez‐Mejíasa, Hanying Li, Peng Cheng, Francisco W. Cruz, Giselle Utida, Youwei Li, Miaomiao Wang, Yueer Li, Xuexue Jia, Youfeng Ning, Hai Cheng   +14 more
doaj   +1 more source

Development and Evaluation of an Explicit Treatment of Aerosol Processes at Cloud Scale Within a Multi‐Scale Modeling Framework (MMF)

Journal of Advances in Modeling Earth Systems, 2018
Modeling the aerosol lifecycle in traditional global climate models (GCM) is challenging for a variety of reasons, not the least of which is the coarse grid.
Guangxing Lin, Steven J. Ghan, Minghuai Wang, Po‐Lun Ma, Richard C. Easter, Mikhail Ovchinnikov, Jiwen Fan, Kai Zhang, Hailong Wang, Duli Chand, Yun Qian   +10 more
doaj   +1 more source

Geodynamic contributions to global climatic change [PDF]

Orbital and rotational variations perturb the latitudinal and seasonal pattern of incident solar radiation, producing major climatic change on time scales of 10(exp 4)-10(exp 6) years.
Bills, Bruce G.
core   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Building trust in large-scale water quality models: 13 alternative strategies beyond validation

Discover Water
Validating large-scale water quality models is challenging because of the variety of water quality constituents, and scales for which observations are limited.
Maryna Strokal, Mengru Wang, Ilaria Micella, Annette B. G. Janssen   +3 more
doaj   +1 more source