Results 71 to 80 of about 6,711,226 (342)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Comment on: “Challenging the Odds: Long‐Term Survival in Pediatric Diffuse Midline Glioma With H3 K27M and BRAF V600 Co‐Mutations Treated With Upfront Radiotherapy and Targeted Therapy”

Pediatric Blood &Cancer, EarlyView.
Natália Dassi, Andrea Maria Cappellano
wiley   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Geodynamic contributions to global climatic change [PDF]

Orbital and rotational variations perturb the latitudinal and seasonal pattern of incident solar radiation, producing major climatic change on time scales of 10(exp 4)-10(exp 6) years.
Bills, Bruce G.
core   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Interhemispheric Monsoon Response to Bipolar Forcing During Heinrich Stadial 4

Geophysical Research Letters
Heinrich Stadial 4 (HS4) the most prominent iceberg collapse event of the Last Glacial and a key example for studying millennial‐scale events. Based on an improved chronological, we present high‐resolution, annually laminated speleothem record from ...
Rui Zhang, Haiwei Zhang, Christoph Spötl, Xiyu Dong, Carlos Pérez‐Mejíasa, Hanying Li, Peng Cheng, Francisco W. Cruz, Giselle Utida, Youwei Li, Miaomiao Wang, Yueer Li, Xuexue Jia, Youfeng Ning, Hai Cheng   +14 more
doaj   +1 more source

Development and Evaluation of an Explicit Treatment of Aerosol Processes at Cloud Scale Within a Multi‐Scale Modeling Framework (MMF)

Journal of Advances in Modeling Earth Systems, 2018
Modeling the aerosol lifecycle in traditional global climate models (GCM) is challenging for a variety of reasons, not the least of which is the coarse grid.
Guangxing Lin, Steven J. Ghan, Minghuai Wang, Po‐Lun Ma, Richard C. Easter, Mikhail Ovchinnikov, Jiwen Fan, Kai Zhang, Hailong Wang, Duli Chand, Yun Qian   +10 more
doaj   +1 more source

Field Simulation of Global Change: Transplanting Northern Bog Mesocosms Southward [PDF]

, 2010
A large proportion of northern peatlands consists of Sphagnum-dominated ombrotrophic bogs. In these bogs, peat mosses (Sphagnum) and vascular plants occur in an apparent stable equilibrium, thereby sustaining the carbon sink function of the bog ecosystem.
Berendse, F., Breeuwer, A.J.G., Heijmans, M.M.P.D., Robroek, B.J.M.   +3 more
core   +2 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Building trust in large-scale water quality models: 13 alternative strategies beyond validation

Discover Water
Validating large-scale water quality models is challenging because of the variety of water quality constituents, and scales for which observations are limited.
Maryna Strokal, Mengru Wang, Ilaria Micella, Annette B. G. Janssen   +3 more
doaj   +1 more source