Results 121 to 130 of about 771,875 (370)

The impact of children's and young adult literature courses on teachers' selection of global and culturally diverse texts for the classroom [PDF]

Lauren Aimonette Liang, Raven Cromwell, Douglas J. Hacker   +2 more
openalex   +1 more source

Advances in Single‐Cell Sequencing for Infectious Diseases: Progress and Perspectives

Advanced Science, EarlyView.
Single‐cell sequencing technologies uncover novel, unknown, and emergent features of many diseases. This review describes recent progress of single‐cell sequencing technologies and their applications in infectious diseases, summarizes the underlying commonalities of different infections and discusses future research directions, facilitating the ...
Mengyuan Lyu, Yang Liu, Jian Zhou, Hongli Lai, Hongxia Ruan, Dongsheng Wu, Shun Zhu, Xudong Zhou, Wananqi Ma, Yuchen Huang, Shuting Lei, Han Luo, Jie Chen, Binwu Ying   +13 more
wiley   +1 more source

Child development and the aims of road safety education [PDF]

, 1996
Pedestrian accidents are one of the most prominent causes of premature injury, handicap and death in the modern world. In children, the problem is so severe that pedestrian accidents are widely regarded as the most serious of all health risks facing ...
Department for Transport (Funder), Foot, H.C., McLaren, B., Thomson, J., Tolmie, Andrew   +4 more
core  

Pyruvate Carboxylase in Macrophages Aggravates Atherosclerosis by Regulating Metabolism Reprogramming to Promote Inflammatory Responses Through the Hypoxia‐Inducible Factor‐1 Signaling Pathway

Advanced Science, EarlyView.
This study investigates the role of macrophage pyruvate carboxylase (PC) in atherosclerosis (AS) demonstrating that PC upregulation in macrophages promotes metabolism reprogramming to enhance inflammatory responses via the HIF‐1 signaling pathway.
Ling‐Na Zhao, Rui‐Ling Wang, Ran‐Xin Liu, Meng‐Ru Zheng, Li Zhao, Bao‐Feng Li, Jia‐Le Li, De‐Shen Liu, Xiao‐Xia He, Qin‐Bao Peng, Kai Li, Tian‐Xiao Lin, Ying‐Ying Liu, Sheng‐Ping He, Jun Lu, Shao‐Yi Zheng, Xiu Liu, Fang‐Ze Huang   +17 more
wiley   +1 more source

Semaphorin 3E‐Plexin‐D1 Pathway Downstream of the Luteinizing Hormone Surge Regulates Ovulation, Granulosa Cell Luteinization, and Ovarian Angiogenesis in Mice

Advanced Science, EarlyView.
The Semaphorin 3E (Sema3E)‐Plexin‐D1 pathway mediated by C/EBPα and C/EBPβ downstream of the luteinizing hormone (LH) surge plays important roles in the mouse preovulatory ovary. Timely activation and suppression of this pathway during the preovulatory stage are crucial for ovulation, corpus luteum formation, and proper angiogenesis.
Hanxue Zhang, Jimmy Dhillon, Paul D. Soloway, Bo Shui, Seoyeon Lee, Jennifer K. Grenier, Paul R. Munn, M. Cecilia Ljungberg, Rebecca B Williams, Rainer B. Lanz, Yu‐Hsiang Liao, Yi A. Ren   +11 more
wiley   +1 more source

Inhibition of Phosphodiesterase 10A by MP‐10 Rescues Behavioral Deficits and Normalizes Microglial Morphology and Synaptic Pruning in A Mouse Model of FOXP1 Syndrome

Advanced Science, EarlyView.
We demonstrate that Foxp1± mice, modeling FOXP1 haploinsufficiency, exhibit behavioral deficits, striatal neuroinflammatory changes including altered microglial complexity and synaptic pruning, and markedly reduced Pde10a expression. Pde10a inhibition starting immediately after birth restores Foxp1± behavior, microglial morphology, and pruning ...
Henning Fröhlich, Jing Wang, Ferdinand Althammer, Tim Schubert, Nina Kluck, Valery Grinevich, Stefanie Schmitteckert, Christian P. Schaaf, Gudrun A. Rappold   +8 more
wiley   +1 more source

Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine

Advanced Science, EarlyView.
Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang, Feng Gao, Liqun Yu, Haokun Chen, Rongrong Zhu   +4 more
wiley   +1 more source

RPL6 Interacts with HMGCS1 to Stabilize HIF‐1α by Promoting Cholesterol Production in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The study found that RPL6 is frequently upregulated in HCC tissues with extrahepatic metastasis. Elevated RPL6 bound to and increased the stability of HMGCS1 mRNA, thereby enhancing intracellular cholesterol levels. Subsequently, increased cholesterol promotes cancer metastasis in HCC by stabilizing HIF‐1α protein.
Minli Yang, Shengtao Cheng, Huiying Gu, Shan Zhong, Dapeng Zhang, Xin He, Weixian Chen, Haijun Deng, Jihua Ren, Peng Chen, Ming Tan, Hui Zhang, Fan Li, Zhenzhen Zhang, Yuan Hu, Juan Chen   +15 more
wiley   +1 more source

A MXene‐Based Nanothermal Knife Inhibits Aggresome‐Mediated Persister Formation for Preventing Dental Caries

Advanced Science, EarlyView.
Early childhood caries (ECC) involves cariogenic persisters that evade antimicrobial treatment. Persisters achieve this by downregulating heat shock proteins (HSPs) and formation of protein aggregates. Ti3C2 MXene‐based photothermal therapy (PTT) acts as a “nanothermal knife,” disrupting membranes, upregulating HSPs, inhibits aggregates, prevents ...
Yinyin Zhang, Leilei Yang, Jing jiao, Wenshuai Li, Sen Lin, Xianlong Zong, Haoyang Qin, Danfeng Liu, Rui Li   +8 more
wiley   +1 more source

Emerging Nanotechnology Strategies for Obesity Therapy

Advanced Science, EarlyView.
Three types of nanomaterials used for obesity treatment are highlighted, including inorganic nanomaterials, organic nanomaterials and biomimetic nanomaterials. A detailed and comprehensive introduction to the recent nanotechnology strategies for obesity management is also provided, including drug delivery, photodynamic therapy, hyperthermia, gas ...
Weili Chang, Zhaoxu Meng, Yuezhu Zhao, Yake Qi, Zhou Li, He Lian   +5 more
wiley   +1 more source