Results 51 to 60 of about 1,616,626 (306)

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

Managerial Economics and Global Competition

open access: yesSymphonya, 2005
Global managerial economics tends to emerge in conditions of strong, continuous competitive tension, in contexts that are open and subject to political, social and technological instability.
Silvio M. Brondoni
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

open access: yesMolecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li   +10 more
wiley   +1 more source

THE IMPACT OF GLOBAL COMPETITION ON THE STATE OF MANUFACTURING IN UKRAINE AND DEVELOPED COUNTRIES

open access: yesBaltic Journal of Economic Studies, 2017
At the end of the 20th century, the economic structure was changed fundamentally in some countries. It was mostly related to the growth of global competition.
Kateryna Shatnenko
doaj  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Changing Identities. From DiverseyLever to JohnsonDiversey: a Case of Cultural Integration

open access: yesSymphonya, 2002
The Diversey acquisition from the Unilever group was official the 1st April 1996. The final aim of this operation consisted in a merger between the new acquired company and Industrial Lever to create a new world leader reality in the industrial cleaning
Liberato Angellotti   +3 more
doaj   +1 more source

Human Resources in the Future: An Obstacle or a Champion of Globalization? [PDF]

open access: yes, 1996
[Excerpt] There seems to be a wide ranging agreement among HR scholars and practitioners alike that HR in the Future will be increasingly global. Virtually no firms, large or small, irrespective of industries, are today shielded from the impact of ...
Pucik, Vladimir
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

Global Banking: Transformation, Innovation & Competition

open access: yesSHS Web of Conferences, 2017
The article discusses the main transformation processes in banking sector: globalization, concentration of capital, formation of a new model of banking and new banking culture.
Korobov Yury
doaj   +1 more source

Home - About - Disclaimer - Privacy