Results 111 to 120 of about 13,208,906 (298)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

Global Education Digest 2024

open access: yes
This is the seventh edition of ANGEL’s Global Education Digest, which is now a well-established facet of ANGEL's efforts to support scholars, policymakers, and practitioners from all over the world who are interested in the topic of global education and ...
ANGEL, .
core   +1 more source

International Education, United Nations Sustainable Development Goals, and ASM Ambassadors

open access: yesJournal of Microbiology & Biology Education
Global, high-quality education is crucial for achieving the United Nations Sustainable Development Goals.
Stanley Maloy
doaj   +1 more source

Linking Global Citizenship Education and Education for Democracy through Social Justice: What can we learn from the perspectives of teacher - education candidates [PDF]

open access: yes, 2014
The respective projects of education for global citizenship and education for democracy are inherently intertwined; the richness and salience of one is dependent on the expression of the other.
Pluim, Gary   +2 more
core  

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

open access: yesMolecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth   +17 more
wiley   +1 more source

Global psychiatric education [PDF]

open access: yesInternational Review of Psychiatry, 2020
openaire   +2 more sources

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

El ingeniero global en el desarrollo humano y sostenible

open access: yes
Obra formada per: Bloque A "El ingeniero global" (Vol. 1. La necesidad del ingeniero global. Vol. 2. Los elementos clave para afrontar la dimensión global de la ingeniería. Vol. 3.
Global Dimension in Engineering Education
core  

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