Results 121 to 130 of about 1,146,140 (311)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
News versus Newsfeed: The Impact of Social Media on Global Citizenship Education [PDF]
, 2017 Suas Educational Development has worked since its inception to engage third level students in Ireland in global citizenship education. This article focuses on some of the challenges of supporting young people in reflecting, learning and acting on global
Emma Somers
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Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
Global education for urban futures [PDF]
, 2015 Urban Pamphleteer #5: Global Education for Urban Futures (September 2015), aims to stimulate a critical discussion about the future of higher education focused on cities and ...
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FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
School-related gender-based violence is preventing the achievement of quality education for all [PDF]
, 2015 This policy paper argues that school-related gender-based violence (SRGBV) is a global concern preventing children, especially girls, exercising their right to a safe, inclusive and quality education.
Education for all Global Monitoring Report
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MiR‐513a promotes human erythroid differentiation by modulating c‐Jun
FEBS Open Bio, EarlyView.During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim +11 more
wiley +1 more source
Global psychiatric education [PDF]
International Review of Psychiatry, 2020 openaire +2 more sources
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
The Implications of the Local Context in Global Online Education
International Review of Research in Open and Distributed Learning, 2012 This paper investigates how features in students’ everyday life influence their participation in online global collaboration, and it suggests that students’ local context should be recognised as a significant part of their educational space.
Ståle Angen Rye and Anne Marie Støkken
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