Results 41 to 50 of about 1,146,140 (311)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
London Review of Education, 2022 This article discusses three (among many) contributions made by Jagdish S. Gundara (1938–2016) to the IOE (Institute of Education), UCL’s Faculty of Education and Society (University College London, UK).
doaj +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
TYPES OF SECURITY EDUCATION IN POLAND. SELECTED EXAMPLES
Security and Defence Quarterly, 2018 The purpose of the article is to examine selected examples of types of security education in Poland. At the beginning of the 20th century, national security was centered on military and political aspects, but recent decades have seen the successive ...
Marlena ZADOROŻNA
doaj +1 more source
Exploring knowledge production and policy shifts in global higher education [PDF]
Higher education is undergoing significant transformation in response to global pressures such as policy shifts, internationalization, and changing governance models.
Özkan, Metin +2 more
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Operating between Cultures and Langugages: Multilingual Films in Foreign Language Classes
PraxisForschungLehrer*innenBildung, 2020 Our societies have undergone two major changes during the last decades: firstly, the continuous rise of cultural and linguistic diversity, due to the global economy, migration and universal mobility, and secondly, the steady expansion and gathering ...
Gabriele Blell
doaj +1 more source
Informal Spaces in Global Citizenship Education [PDF]
, 2018 Literature on global citizenship education (GCE) has helped to build a framework of best practice for its implementation and delivery. Creating safe spaces and open environments for teaching, learning and discussion have been widely supported by scholars.
Le Bourdon, M +2 more
core
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Teaching & Learning Inquiry: The ISSOTL Journal, 2021 In this qualitative study, 26 university students reflected on their experiences in domestic or international study away programs. Utilizing a sociocultural developmental framework, we examined perceived changes in identity in relation to salient aspects
Maureen Vandermaas-Peeler +5 more
doaj +1 more source