Results 51 to 60 of about 4,325,785 (312)
Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion
Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana +8 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
NH International Seminar, Spring 2017: Migrations, Labor, and Natural Resources [PDF]
, 2017 Nicole ConstableProfessor of Anthropology, University of PittsburghFebruary 7, 2017 Precarious Labor Migrations in Asia: An Anthropologist\u27s Perspective Mary MaloneAssociate Professor of Political Science, UNHMarch 21, 2017 Leaving the Devil You Know:
Center for International Education and Global Engagement
core +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
NH International Seminar, Spring 2016: Identity, Marginality & Community [PDF]
, 2016 NHIS Spring 2016 - Identity, Marginality & Community Thursday, February 11, 2:10 – 3:30 pm, MUB Theater IIMarla Brettschneider, UNH Department of Women\u27s Studies and Political Science The Jewish Phenomenon in Sub-Saharan Africa Wednesday, March 2, 4 ...
Center for International Education and Global Engagement
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
The implications of the local context in global virtual education
International Review of Research in Open and Distributed Learning, 2012 This paper investigates how features in students’ everyday life influence their participation in online global collaboration, and it suggests that students’ local context should be recognised as a significant part of their educational space.
Ståle Angen Rye, Anne Marie Støkken
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
International Review of Research in Open and Distributed Learning, 2019 The advancement of mobile communication technology has contributed to an increasingly interconnected world; however, these devices are not being used as effectively as they could be to improve global challenges.
Evan Michael Fox
doaj +1 more source