Results 61 to 70 of about 4,325,785 (312)
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
全球教育的重要主題及其課程設計On Key Themes of Global Education and Their
Journal of Curriculum Studies, 2012 有鑑於全球化的趨勢與衝擊愈來愈明顯，各國紛紛重視國際或全球教育的改革，尤其希望透過課程與教學的調整，培育具備國際觀、全球行動與競爭力的人才。本研究旨在探討全球教育課程的重要主題，並分析我國在國際教育課程設計上的現況與重點。首先，分析全球教育課程的內涵，繼之彙整英國與澳洲的課程設計實例，並進而探討全球教育課程設計的三類模式及其重要主題，包括第一類是透過五大類主題來彰顯全球教育內涵；第二類是透過全球性議題來建立全球公民素養；第三類則是透過合作專案學習來擴展國際視野 ...
林永豐 Yung-Feng Lin
doaj +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Refugee Students Arrive at a School: What Happens Next?
Global Education Review, 2018 As refugee children join classrooms across the world, schools have the opportunity to expand the global education of all students. Students, teachers, administrators, and families may partner together to form supportive environments.
Keri-Anne Croce
doaj
Investigating Student Use of Technology for Engaged Citizenship in A Global Age
Education Sciences, 2012 This study undertook a five month qualitative investigation into technology use amongst twelve high school social studies students in two different sites in the Midwestern United States.
Brad M. Maguth
doaj +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Building Interprofessional Global Health Infrastructure at a University and Health System: Navigating Challenges and Scaling Successes [PDF]
, 2017 Mission: Global Jefferson will create sustainable programs of global distinction through collaboration that position Jefferson as a local and international destination and resource for education, research, and clinical activities.
Bogen, MA, Janice +6 more
core +2 more sources
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source