Results 71 to 80 of about 1,146,140 (311)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Integrating GDE into research [PDF]
, 2014 Obra formada per: Block A "The global engineer" (Vol. 1. Making the case for a critical global engineer. Vol. 2. Key elements for addressing the global dimension of engineering. Vol. 3.
Global Dimension in Engineering Education
core +2 more sources
Education for Social Change: The Global Learning Programme in the North of Ireland [PDF]
, 2016 The Global Learning Programme (GLP) is a four-year initiative funded by the UK government that aims ‘to support schools to teach about global poverty and international development, with a particular focus on upper primary and early secondary school ...
Stephen McCloskey
core
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
The implications of the local context in global virtual education
International Review of Research in Open and Distributed Learning, 2012 This paper investigates how features in students’ everyday life influence their participation in online global collaboration, and it suggests that students’ local context should be recognised as a significant part of their educational space.
Ståle Angen Rye, Anne Marie Støkken
doaj +1 more source
Exploring Global Citizenship Education through Integrated Curricula [PDF]
, 2016 This article is informed by a qualitative case study of a primary school in England which developed an integrated school curriculum which focused on global citizenship education (GCE).
Brighid Golden
core
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
International Review of Research in Open and Distributed Learning, 2019 The advancement of mobile communication technology has contributed to an increasingly interconnected world; however, these devices are not being used as effectively as they could be to improve global challenges.
Evan Michael Fox
doaj +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source