Results 51 to 60 of about 4,298,312 (312)
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
The implications of the local context in global virtual education
International Review of Research in Open and Distributed Learning, 2012 This paper investigates how features in students’ everyday life influence their participation in online global collaboration, and it suggests that students’ local context should be recognised as a significant part of their educational space.
Ståle Angen Rye, Anne Marie Støkken
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
International Review of Research in Open and Distributed Learning, 2019 The advancement of mobile communication technology has contributed to an increasingly interconnected world; however, these devices are not being used as effectively as they could be to improve global challenges.
Evan Michael Fox
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LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
全球教育的重要主題及其課程設計On Key Themes of Global Education and Their
Journal of Curriculum Studies, 2012 有鑑於全球化的趨勢與衝擊愈來愈明顯，各國紛紛重視國際或全球教育的改革，尤其希望透過課程與教學的調整，培育具備國際觀、全球行動與競爭力的人才。本研究旨在探討全球教育課程的重要主題，並分析我國在國際教育課程設計上的現況與重點。首先，分析全球教育課程的內涵，繼之彙整英國與澳洲的課程設計實例，並進而探討全球教育課程設計的三類模式及其重要主題，包括第一類是透過五大類主題來彰顯全球教育內涵；第二類是透過全球性議題來建立全球公民素養；第三類則是透過合作專案學習來擴展國際視野 ...
林永豐 Yung-Feng Lin
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NH International Seminar, Spring 2017: Migrations, Labor, and Natural Resources [PDF]
, 2017 Nicole ConstableProfessor of Anthropology, University of PittsburghFebruary 7, 2017 Precarious Labor Migrations in Asia: An Anthropologist\u27s Perspective Mary MaloneAssociate Professor of Political Science, UNHMarch 21, 2017 Leaving the Devil You Know:
Center for International Education and Global Engagement
core +1 more source