Results 121 to 130 of about 2,426,099 (326)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

Global boundedness and stability of a quasilinear two-species chemotaxis-competition model with nonlinear sensitivities

open access: yesAdvances in Nonlinear Analysis
This study deals with the global boundedness of a classical solution to a quasilinear two-species chemotaxis-competition model with nonlinear sensitivities in n≤3n\le 3. Due to the presence of nonlinear sensitivities, obtaining the necessary ‖w‖L∞\Vert w{
Yan Dongze, Liu Changchun
doaj   +1 more source

Global existence of classical static solutions of four dimensional Einstein-Klein-Gordon system [PDF]

open access: green, 2022
Mirda Prisma Wijayanto   +3 more
openalex   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

open access: yesMolecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz   +12 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Blow-up for p-Laplacian parabolic equations

open access: yesElectronic Journal of Differential Equations, 2003
In this article we give a complete picture of the blow-up criteria for weak solutions of the Dirichlet problem $$ u_t= abla(| abla u|^{p-2} abla u)+lambda |u|^{q-2}u,quad hbox{in } Omega_T, $$ where $p>1$.
Yuxiang Li, Chunhong Xie
doaj  

Boundedness of solutions in a two-species chemotaxis system

open access: yesElectronic Research Archive
In this paper, we consider an initial-Neumann boundary value problem for a two-species chemotaxis system \begin{document}$ \begin{equation*} \left\{ \begin{array}{ll} \frac{\partial u}{\partial t} = \Delta u-\chi\nabla \cdot (u\nabla w)+u(a_{1}-b_{1}u^{
Chang-Jian Wang, Yuan-Hao Zang
doaj   +1 more source

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