Results 71 to 80 of about 5,020,641 (311)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Optimization of the standard genetic code according to three codon positions using an evolutionary algorithm. [PDF]

PLoS ONE, 2018
Many biological systems are typically examined from the point of view of adaptation to certain conditions or requirements. One such system is the standard genetic code (SGC), which generally minimizes the cost of amino acid replacements resulting from ...
Paweł Błażej, Małgorzata Wnętrzak, Dorota Mackiewicz, Paweł Mackiewicz   +3 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Global Modeling and Target Optimality [PDF]

, 1980
This article's point of departure is the observation that global modelers characteristically do not justify their policy recommendations in terms of social optimality criteria.
Snower, D.
core   +1 more source

A solution method for the traveling salesman problem based on multi-scale features and dynamic optimization

Discover Computing
As a classic NP-hard problem, the Traveling Salesman Problem (TSP) exhibits exponentially increasing complexity with node quantity, making optimal solutions difficult for large-scale instances. Traditional exact and heuristic algorithms still struggle to
Yuting Xie, Qianqian Duan
doaj   +1 more source

Fractional Calculus Approach for Variational Problems: Characterization of Sufficient Optimality Conditions and Duality

Partial Differential Equations in Applied Mathematics
In this paper, we present a Wolfe-type dual model containing the Caputo-Fabrizio fractional derivative, weak and strong duality results, number of Kuhn-Tucker type sufficient optimality conditions and duality results for variational problems (VPs) with ...
Ved Prakash Dubey, Devendra Kumar, Jagdev Singh, Dumitru Baleanu   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

An updated definition of global health

The most cited definition of global health, published in The Lancet in 2009, defines global health as "an area for study, research, and practice that places a priority on improving health and achieving equity in health for all people worldwide".
Waggett, Caryl E., Landrigan, Philip J., Martin, Keith W., Bruchhausen, Walter, Li, Hao, Grant, Liz, Gostin, Lawrence O., Davidson, Patricia M., Seymour, Brittany, Raviglione, Mario C., Jacobsen, Kathryn H., Garzon-Villalba, Ximena, Chowdhury, Shahanaz, Reynolds, Nancy R., Sewankambo, Nelson K., Adeyi, Olusoji   +15 more
core   +1 more source

Computational Optimality Theory

, 1995
In Optimality Theory, a linguistic input is assigned a grammatical structural description by selecting, from an infinite set of candidate structural descriptions, the description which best satisfies a ranked set of universal constraints.

core   +1 more source

Modern Methods for Solving Nonconvex Optimal Control Problems

Известия Иркутского государственного университета: Серия "Математика", 2014
The paper presents a few remarks on the evolution of Irkutsk’s school of O. V. Vasiliev on optimal control methods based on Pontryagin principle. Besides, one reviews some features of Pontryagin principle, in particular, its sufficiency and constructive ...
A.S. Strekalovsky
doaj