Results 81 to 90 of about 5,020,641 (311)

Optimality Conditions for Mathematical Programs with Vanishing Constraints Using Directional Convexificators

open access: yesAxioms
This article deals with mathematical programs with vanishing constraints (MPVCs) involving lower semi-continuous functions. We introduce generalized Abadie constraint qualification (ACQ) and MPVC-ACQ in terms of directional convexificators and derive ...
Ram Narayan Mohapatra   +2 more
doaj   +1 more source

Novelty search for global optimization

open access: yesApplied Mathematics and Computation, 2019
Novelty search is a tool in evolutionary and swarm robotics for maintaining the diversity of population needed for continuous robotic operation. It enables nature-inspired algorithms to evaluate solutions on the basis of the distance to their k-nearest neighbors in the search space.
Iztok Fister 0001   +7 more
openaire   +5 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

On optimality in intergenerational risk sharing [PDF]

open access: yes
This paper defines and studies optimality in a dynamic stochastic economy with finitely lived agents, and investigates the optimality properties of an equilibrium with or without sequentially complete markets.
Gabrielle Demange
core  

Optimality and Wh-Extraction

open access: yes, 1995
In this paper, we propose to start addressing the issues outlined above from the perspective of Optimality Theory (OT, Prince and Smolensky, 1993) and test the hypothesis that different patterns of extractability across languages result from different ...
Raymond, William   +4 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

First order optimality condition for constrained set-valued optimization [PDF]

open access: yes
A constrained optimization problem with set-valued data is considered. Different kind of solutions are defined for such a problem. We recall weak minimizer, efficient minimizer and proper minimizer.
Rocca Matteo   +2 more
core  

Global dataset for "Global leaf-trait mapping based on optimality theory "

open access: yes, 2022
This repository contains Global data used for “Global leaf-trait mapping based on optimality theory” published in GEB. Global_Maps_SLA represents climatology of published Global SLA used for comparison (details products see table 1 and figure 4 ...
Wright, Ian   +4 more
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

Hodges-Lehmann Optimality for Testing Moment [PDF]

open access: yes
This paper studies the Hodges and Lehmann (1956) optimality of tests in a general setup. The tests are compared by the exponential rates of growth to one of the power functions evaluated at a fixed alternative while keeping the asymptotic sizes bounded ...
Ivan Canay, Taisuke Otsu
core  

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