Results 111 to 120 of about 10,424 (290)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Optimality conditions and optimization methods for quartic polynomial optimization

, 2014
In this paper multivariate quartic polynomial optimization program (QPOP) is considered. Quartic optimization problems arise in various practical applications and are proved to be NP hard.
Wu, Zhiyou, Ugon, Julien, Quan, Jing, Tian, Jing   +3 more
core   +2 more sources

Dynamic Programming-Based Model Predictive Control of Energy Management for a Novel Plug-In Hybrid Electric Vehicle

Energies
To address the conflict between real-time performance and global optimality in the energy management of dual-motor plug-in hybrid electric vehicles (PHEVs), this paper proposes a model predictive control (MPC) strategy based on dynamic programming (DP ...
Shunzhang Zou, Jun Zhang, Yunfeng Liu, Yu Yang, Yunshan Zhou, Jingyang Peng, Guolin Wang   +6 more
doaj   +1 more source

The Deterministic Impulse Control Maximum Principle in Operations Research: Necessary and Sufficient Optimality Conditions (replaces CentER DP 2011-052)

This paper considers a class of optimal control problems that allows jumps in the state variable. We present the necessary optimality conditions of the Impulse Control Maximum Principle based on the current value formulation.
Chahim, M., Hartl, R.F., Kort, P.M.
core  

New optimality conditions for nonsmooth control problems

, 2012
This work considers nonsmooth optimal control problems and provides two new sufficient conditions of optimality. The first condition involves the Lagrange multipliers while the second does not.
de Oliveira, Valeriano Antunes [UNESP], de Oliveira, Valeriano Antunes, Silva, Geraldo Nunes, Silva, Geraldo Nunes [UNESP]   +3 more
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

On sufficient optimality conditions for multiobjective control problems

, 2016
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Processo FAPESP: 2013/07375-0Processo FAPESP: 309335/2012-4Processo FAPESP: 457785/2014-4Processo FAPESP: 479109/2013-3This paper is devoted to presenting optimality conditions for the ...
de Oliveira, Valeriano Antunes [UNESP], de Oliveira, Valeriano Antunes, Silva, Geraldo Nunes, Silva, Geraldo Nunes [UNESP]   +3 more
core   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Equivalent formulations and necessary optimality conditions for the lennard–jones problem

, 2002
© 2002Kluwer Academic Publishers. Printed in the Netherlands. The minimization of molecular potential energy functions is one of the most challenging, unsolved nonconvex global optimization problems and plays an important role in the determination of ...
Shen, Zuo–Jun, Pardalos, Panos M., Huang, Hong–Xuan   +2 more
core   +1 more source