Results 101 to 110 of about 10,424 (290)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

A Voronoi–A* Fusion Algorithm with Adaptive Layering for Efficient UAV Path Planning in Complex Terrain

Drones
Unmanned Aerial Vehicles (UAVs) face significant challenges in global path planning within complex terrains, as traditional algorithms (e.g., A*, PSO, APF) struggle to balance computational efficiency, path optimality, and safety.
Boyu Dong, Gong Zhang, Yan Yang, Peiyuan Yuan, Shuntong Lu   +4 more
doaj   +1 more source

A note on sufficient global optimality conditions for fixed charge quadratic programs

, 2009
In this work we establish conditions for a feasible point to be a global minimizer of a fixed charge quadratic model program. This program has a wide variety of classic applications, for instance, in facility location, scheduling and portfolio selection.
Srisatkunarajah, S., Jeyakumar, V.
core   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

On the Optimal Policies of Time-Inhomogeneous Unreliable Service Systems

Mathematics
This paper investigates the optimal dynamic policies of time-inhomogeneous unreliable multi-server queueing systems with multiple customer sources and differentiated maintenance speeds. Under the criterion of global revenue optimality, we first elaborate
Yan Su, Jiawen Liu, Ran Zhong
doaj   +1 more source

Global optimality conditions for mixed integer weakly concave programming problems

, 2010
In this paper, some necessary and some suffcient global optimality conditions for a class of mixed integer programming problems whose objective functions are the difference of quadratic functions and convex functions are established.
Wu, Zhiyou, Bai, Fusheng, Quan, Jing
core  

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Safety Control with Adaptive Safety Sets and Belief Dynamics for LAV Under Uncertainty

Drones
This paper presents a novel safety control framework for Loitering Aerial Vehicles (LAVs) operating under non-Gaussian measurement uncertainty. The approach integrates variational inference-based belief dynamics with adaptive buffered half-space ...
Meijiao Zhao, Yidi Wang, Wei Zheng
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source