Results 101 to 110 of about 12,161,396 (244)
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
On the Optimal Policies of Time-Inhomogeneous Unreliable Service Systems
MathematicsThis paper investigates the optimal dynamic policies of time-inhomogeneous unreliable multi-server queueing systems with multiple customer sources and differentiated maintenance speeds. Under the criterion of global revenue optimality, we first elaborate
Yan Su, Jiawen Liu, Ran Zhong
doaj +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Safety Control with Adaptive Safety Sets and Belief Dynamics for LAV Under Uncertainty
DronesThis paper presents a novel safety control framework for Loitering Aerial Vehicles (LAVs) operating under non-Gaussian measurement uncertainty. The approach integrates variational inference-based belief dynamics with adaptive buffered half-space ...
Meijiao Zhao, Yidi Wang, Wei Zheng
doaj +1 more source
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Optimality conditions for discrete-time control problems
, 2020 We consider an optimal control problem governed by a system of nonlinear difference equations. We obtain the existence of the optimal control as well as first-order optimality conditions of Pontryagin type by using the Dubovitskii–Milyutin formalism ...
Batista dos Santos, Lucelina +3 more
core +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
EnergiesTo address the conflict between real-time performance and global optimality in the energy management of dual-motor plug-in hybrid electric vehicles (PHEVs), this paper proposes a model predictive control (MPC) strategy based on dynamic programming (DP ...
Shunzhang Zou +6 more
doaj +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source