Results 91 to 100 of about 12,161,396 (244)
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
On optimality in intergenerational risk sharing [PDF]
This paper defines and studies optimality in a dynamic stochastic economy with finitely lived agents, and investigates the optimality properties of an equilibrium with or without sequentially complete markets.
Gabrielle Demange
core
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Selecciones MatemáticasThe purpose of the present paper is to improve the global convergence results established so far concerning the Augmented Lagrangian Algorithm with exponential penalty function for solving nonlinear programming problems with equality and inequality ...
Frank Navarro Rojas +1 more
doaj +1 more source
A Convex Optimization Algorithm for Electricity Pricing of Charging Stations
Algorithms, 2019 The problem of electricity pricing for charging stations is a multi-objective mixed integer nonlinear programming. Existing algorithms have low efficiency in solving this problem.
Jing Zhang +7 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
A Semidefinite Programming Approach for Harmonic Balance Method
IEEE Access, 2019 The harmonic balance method is broadly employed for analyzing and predicting the periodic steady-state solution. Most of the traditional methods in the literature do not guarantee global optimality. Due to its nonconvexity, it is a complex task to find a
Cheng H. Yang, Ben S. Deng
doaj +1 more source
On constraint qualifications with generalized convexity and optimality conditions [PDF]
This paper deals with a multiobjective programming problem involving both equality constraints in infinite dimensional spaces. It is shown that some constraint qualifications together with a condition of interior points are sufficient conditions for the ...
Do Van Luu, Manh-Hung Nguyen
core
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
DronesUnmanned Aerial Vehicles (UAVs) face significant challenges in global path planning within complex terrains, as traditional algorithms (e.g., A*, PSO, APF) struggle to balance computational efficiency, path optimality, and safety.
Boyu Dong +4 more
doaj +1 more source