Results 71 to 80 of about 12,161,396 (244)

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

TREED (v1.0): a trait- and optimality-based eco-evolutionary vegetation model for the deep past and the present [PDF]

Geoscientific Model Development
We present the TREED model (TRait Ecology and Evolution over Deep time), a trait- and optimality-based vegetation model to simulate vegetation structure, carbon cycling and eco-evolutionary adaptation dynamics to climate and CO2 changes across geologic ...
J. Rogger, J. Rogger, J. Rogger, J. Rogger, K. Gurung, E. B. Kopp, W. J. Matthaeus, B. J. W. Mills, B. D. Stocker, B. D. Stocker, T. V. Gerya, L. Pellissier, L. Pellissier   +12 more
doaj   +1 more source

Global optimality conditions for mixed integer weakly concave programming problems [PDF]

, 2010
In this paper, some necessary and some suffcient global optimality conditions for a class of mixed integer programming problems whose objective functions are the difference of quadratic functions and convex functions are established.
Wu, Zhiyou, Bai, Fusheng, Quan, Jing
core  

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Necessary and sufficient global optimality conditions for NLP reformulations of linear SDP problems

, 2009
In this paper we consider the standard linear SDP problem, and its low rank nonlinear programming reformulation, based on a Gramian representation of a positive semi- definite matrix.
PICCIALLI, VERONICA, Palagi, L, Grippo, L, Piccialli, V   +3 more
core   +2 more sources

The Deterministic Impulse Control Maximum Principle in Operations Research: Necessary and Sufficient Optimality Conditions (replaces CentER DP 2011-052) [PDF]

This paper considers a class of optimal control problems that allows jumps in the state variable. We present the necessary optimality conditions of the Impulse Control Maximum Principle based on the current value formulation.
Chahim, M., Hartl, R.F., Kort, P.M.
core  

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

First-Order Conditions for C0,1 Constrained vector optimization [PDF]

For a Fritz John type vector optimization problem with C0,1 data we define different type of solutions, give their scalar characterizations applying the so called oriented distance, and give necessary and sufficient first order optimality conditions in ...
Rocca Matteo, Ginchev Ivan, Guerraggio Angelo   +2 more
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

A local-restart coupled strategy for simultaneous sizing and geometry truss optimization

Latin American Journal of Solids and Structures
This paper presents an approach for the global optimization of truss sizing and geometry that is based on a probabilistic restart procedure coupled with a local search algorithm.
André Jacomel Torii, Rafael Holdorf Lopez, Marco Antônio Luersen   +2 more
doaj   +1 more source