Results 61 to 70 of about 12,161,396 (244)
Unified global optimality conditions for smooth minimization problems with mixed variables [PDF]
, 2008 In this paper we establish necessary as well as sufficient conditions for a given feasible point to be a global minimizer of smooth minimization problems with mixed variables.
Huy, Nguyen Quang +5 more
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
A Method for Semidefinite Quasiconvex Maximization Problem
Известия Иркутского государственного университета: Серия "Математика", 2016 We introduce so-called semidefinite quasiconvex maximization problem. We derive new global optimality conditions by generalizing [9]. Using these conditions, we construct an algorithm which generates a sequence of local maximizers that converges to a ...
R. Enkhbat +3 more
doaj
Journal of Marine Science and EngineeringMulti-vessel formation shipping demonstrates significant potential for enhancing maritime transportation efficiency and economy. However, existing route planning systems inadequately address the unique challenges of formations, where traditional methods ...
Zilong Guo +5 more
doaj +1 more source
First order optimality conditions in set-valued optimization [PDF]
A a set-valued optimization problem minC F(x), x 2 X0, is considered, where X0 X, X and Y are Banach spaces, F : X0 Y is a set-valued function and C Y is a closed cone.
Rocca Matteo +2 more
core
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Global search method for solving Malfatti’s four-circle problem
Известия Иркутского государственного университета: Серия "Математика", 2016 We consider Malfatti’s problem formulated 200 years ago. In the beginning, Malfatti’s problem was supposed to be solved in a geometric construction way. In 1994, it was done by Zalgaller and Los for the original Malfatti’s problem using so-called greedy ...
R. Enkhbat, M. Barkova
doaj
Maximizing the Sum of Radii of Balls Inscribed in a Polyhedral Set
Известия Иркутского государственного университета: Серия "Математика", 2019 The sphere packing problem is one of the most applicable areas in mathematics which finds numerous applications in science and technology [1–4;8;9;11–14].
R. Enkhbat, J. Davaadulam
doaj +1 more source
First order optimality condition for constrained set-valued optimization [PDF]
A constrained optimization problem with set-valued data is considered. Different kind of solutions are defined for such a problem. We recall weak minimizer, efficient minimizer and proper minimizer.
Rocca Matteo +2 more
core