Results 51 to 60 of about 8,714 (262)
Fractional Optimization Problems
Известия Иркутского государственного университета: Серия "Математика", 2014 We consider fractional maximization and minimization problems with an arbitrary feasible set, with a convex function in the numerator, and with a concave function in the denominator. These problems have many applications in economics and engineering.
R. Enkhbat, T. Bayartugs
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Biomath, 2019 Optimal control problems in mathematical epidemiology are often solved by Hamiltonian methods. However, these methods require conditions on the problem to guarantee that they give global solutions.
Vianney Mbatumutima +2 more
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New global optimality conditions for nonsmooth DC optimization problems [PDF]
Journal of Global Optimization, 2019 In this article we propose a new approach to an analysis of DC optimization problems. This approach was largely inspired by codifferential calculus and the method of codifferential descent and is based on the use of a so-called affine support set of a convex function instead of the Frenchel conjugate function.
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Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
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Molecular Oncology, Volume 20, Issue 6, Page 1591-1611, June 2026.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
A Method for Semidefinite Quasiconvex Maximization Problem
Известия Иркутского государственного университета: Серия "Математика", 2016 We introduce so-called semidefinite quasiconvex maximization problem. We derive new global optimality conditions by generalizing [9]. Using these conditions, we construct an algorithm which generates a sequence of local maximizers that converges to a ...
R. Enkhbat +3 more
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Journal of Marine Science and EngineeringMulti-vessel formation shipping demonstrates significant potential for enhancing maritime transportation efficiency and economy. However, existing route planning systems inadequately address the unique challenges of formations, where traditional methods ...
Zilong Guo +5 more
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LOCAL AND GLOBAL OPTIMALITY CONDITIONS FOR DC INFINITE OPTIMIZATION PROBLEMS
Taiwanese Journal of Mathematics, 2014 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Fang, D. H., Zhao, X. P.
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Molecular Oncology, Volume 20, Issue 6, Page 1494-1512, June 2026.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source