Results 41 to 50 of about 8,714 (262)
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
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Necessary and Sufficient Second-Order Optimality Conditions on Hadamard Manifolds
Mathematics, 2020 This work is intended to lead a study of necessary and sufficient optimality conditions for scalar optimization problems on Hadamard manifolds. In the context of this geometry, we obtain and present new function types characterized by the property of ...
Gabriel Ruiz-Garzón +3 more
doaj +1 more source
Mathematics, 2023 The optimal control problems for stationary magnetohydrodynamic equations under the inhomogeneous mixed boundary conditions for a magnetic field and the Dirichlet condition for velocity are considered.
Gennadii Alekseev
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Optimality conditions and algorithms for integral global minimization
Computers & Mathematics with Applications, 2006 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Hongquan Cui +2 more
openaire +2 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Modern Methods for Solving Nonconvex Optimal Control Problems
Известия Иркутского государственного университета: Серия "Математика", 2014 The paper presents a few remarks on the evolution of Irkutsk’s school of O. V. Vasiliev on optimal control methods based on Pontryagin principle. Besides, one reviews some features of Pontryagin principle, in particular, its sufficiency and constructive ...
A.S. Strekalovsky
doaj
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Efficient use of optimality conditions in Interval Branch and Bound methods
EURO Journal on Computational OptimizationThe Interval Branch and Bound (IBB) method is a widely used approach for solving nonlinear programming problems where a rigorous solution is required. The method uses Interval Arithmetic (IA) to handle rounding errors in calculations.
Mihály Gencsi, Boglárka G.-Tóth
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FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source