Results 81 to 90 of about 12,161,396 (244)

Global optimality conditions for some classes of polynomial integer programming problems [PDF]

open access: yes, 2011
In this paper, some verifiable necessary global optimality conditions and sufficient global optimality conditions for some classes of polynomial integer programming problems are established.
Wu, Zhiyou, Quan, Jing, Li, Guoquan
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Inflectional morphology in optimality theory [PDF]

open access: yes, 2007
P158.42 Optimality theory (Linguistics) -- Grammar, Comparative and general ...
Zheng, X., Xu, Zheng
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Optimality Conditions for Semivectorial Bilevel Convex Optimal Control Problems [PDF]

open access: yes
We present optimality conditions for bilevel optimal control problems where the upper level, to be solved by a leader, is a scalar optimal control problem and the lower level, to be solved by several followers, is a multiobjective convex optimal control ...
Henry Bonnel, Jacqueline Morgan
core  

Non-convex quadratic minimization problems with quadratic constraints: Global optimality conditions

open access: yes, 2007
In this paper, we first examine how global optimality of non-convex constrained optimization problems is related to Lagrange multiplier conditions. We then establish Lagrange multiplier conditions for global optimality of general quadratic minimization ...
Wu, Zhiyou   +2 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Stochastic Bilevel Program for Optimal Coordinated Energy Trading of an EV Aggregator

open access: yesEnergies, 2019
Gradually replacing fossil-fueled vehicles in the transport sector with Electric Vehicles (EVs) may help ensure a sustainable future. With regard to the charging electric load of EVs, optimal scheduling of EV batteries, controlled by an aggregating agent,
Yelena Vardanyan, Henrik Madsen
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach   +9 more
wiley   +1 more source

Hodges-Lehmann Optimality for Testing Moment [PDF]

open access: yes
This paper studies the Hodges and Lehmann (1956) optimality of tests in a general setup. The tests are compared by the exponential rates of growth to one of the power functions evaluated at a fixed alternative while keeping the asymptotic sizes bounded ...
Ivan Canay, Taisuke Otsu
core  

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