Results 51 to 60 of about 1,466,009 (282)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

EOFA: An Extended Version of the Optimal Foraging Algorithm for Global Optimization Problems

Computation
The problem of finding the global minimum of a function is applicable to a multitude of real-world problems and, hence, a variety of computational techniques have been developed to efficiently locate it.
Glykeria Kyrou, Vasileios Charilogis, Ioannis G. Tsoulos   +2 more
doaj   +1 more source

A Family of Hybrid Stochastic Conjugate Gradient Algorithms for Local and Global Minimization Problems

Mathematics, 2022
This paper contains two main parts, Part I and Part II, which discuss the local and global minimization problems, respectively. In Part I, a fresh conjugate gradient (CG) technique is suggested and then combined with a line-search technique to obtain a ...
Khalid Abdulaziz Alnowibet, Salem Mahdi, Ahmad M. Alshamrani, Karam M. Sallam, Ali Wagdy Mohamed   +4 more
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Electrical Storm Optimization (ESO) Algorithm: Theoretical Foundations, Analysis, and Application to Engineering Problems

Machine Learning and Knowledge Extraction
The electrical storm optimization (ESO) algorithm, inspired by the dynamic nature of electrical storms, is a novel population-based metaheuristic that employs three dynamically adjusted parameters: field resistance, field intensity, and field ...
Manuel Soto Calvo, Han Soo Lee
doaj   +1 more source

Automatic Convexity Deduction for Efficient Function’s Range Bounding

Mathematics, 2021
Reliable bounding of a function’s range is essential for deterministic global optimization, approximation, locating roots of nonlinear equations, and several other computational mathematics areas.
Mikhail Posypkin, Oleg Khamisov
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

An Enhanced Tree-Seed Algorithm for Function Optimization and Production Optimization

Biomimetics
As the fields of engineering, energy, and geology become increasingly complex, decision makers face escalating challenges that require skilled solutions to meet practical production needs.
Qingan Zhou, Rong Dai, Guoxiao Zhou, Shenghui Ma, Shunshe Luo   +4 more
doaj   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Augmented Lagrangian Functions for Cone Constrained Optimization: the Existence of Global Saddle Points and Exact Penalty Property

, 2018
In the article we present a general theory of augmented Lagrangian functions for cone constrained optimization problems that allows one to study almost all known augmented Lagrangians for cone constrained programs within a unified framework. We develop a
Dolgopolik, M. V.
core   +1 more source