Results 71 to 80 of about 1,466,009 (282)
A Direct Search Algorithm for Global Optimization
Algorithms, 2016 A direct search algorithm is proposed for minimizing an arbitrary real valued function. The algorithm uses a new function transformation and three simplex-based operations.
Enrique Baeyens +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
GLOBAL OPTIMIZATION METHODS [PDF]
Training a neural network is a difficult optimization problem because of numerous local minimums. Many global search algorithms have been used to train neural networks. However, local search algorithms are more efficient with computational resources, and
Brorsen, B. Wade, Hamm, Lonnie
core +1 more source
Numerical analysis of quantization-based optimization
ETRI JournalWe propose a number-theory-based quantized mathematical optimization scheme for various NP-hard and similar problems. Conventional global optimization schemes, such as simulated and quantum annealing, assume stochastic properties that require multiple ...
Jinwuk Seok, Chang Sik Cho
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Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
InformationThis paper proposes the Open Competency Optimization (OCO) approach, based on adaptive combinatorial operators, to solve the Dynamic Green Traveling Salesman Problem (DG-TSP), which extends the classical TSP by incorporating dynamic travel conditions ...
Rim Benjelloun +2 more
doaj +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Implementation of a fixing strategy and parallelization in a recent global optimization method [PDF]
, 2008 Electromagnetism-like Mechanism (EM) heuristic is a population-based stochastic global optimization method inspired by the attraction-repulsion mechanism of the electromagnetism theory.
Birbil, S. Ilker +3 more
core
Calibration of the E3SM Land Model Using Surrogate‐Based Global Optimization
Journal of Advances in Modeling Earth Systems, 2018 Calibration of the Energy Exascale Earth System Model (E3SM), land model (ELMv0) is challenging because of its model complexity, strong model nonlinearity, and significant computational requirements. Therefore, only a limited number of simulations can be
Dan Lu +3 more
doaj +1 more source