Results 71 to 80 of about 1,342,058 (331)
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
As ruralidades nas políticas globais
Desenvolvimento e Meio Ambiente, 2015 This paper aims at providing a scheme, theoretical and historical as well, of contemporaneous changes of rural societies by referring to the specific experience of west-European countries. This concept of rural – that opened the field of rural sociology –
Marc Mormont
doaj +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Global public goods and health: taking the agenda forward
Bulletin of the World Health Organization, 2001 We examined recent special health initiatives to control HIV/AIDS, malaria, and tuberculosis, and make four policy recommendations for improving the sustainability of such initiatives. First, international cooperation on health should be seen as an issue
Kaul Inge, Faust Michael
doaj
Financing Global Common Goods for Health: When the World is a Country
Health Systems & Reform, 2019 “Global functions” of health cooperation refer to those activities that go beyond the boundaries of individual nations to address transnational issues.
Gavin Yamey +3 more
doaj +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Legitimizing Private Actors in Global Governance: From Performance to Performativity
Politics and Governance, 2017 Global governance is frequently criticised because of major legitimacy deficits, including lack of public accountability and democratic control. Within this context, questions about the legitimacy of non-state governance actors, such as non-governmental ...
Elke Krahmann
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The Belt and Road Initiative and the AIIB: Potential Impact on the Economic Architecture of Asia
Вестник Московского Университета. Серия XXV: Международные отношения и мировая политика, 2020 Dynamics of economic development in Asia in the first two decades of the 21st century can be visualized schematically as a series of waves with different focuses of economic activities of regional powers and prevailing regional economic agenda. The first
Ya. V. Leksyutina
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Aid Financing of Global Public Goods: an Update [PDF]
The paper compares different aggregates of aid financed global public goods and detects the presence, for the period 1995-2006, of the substitution effect between these aggregates and traditional aid that was found by former studies for earlier periods ...
Cepparulo, Alessandra, Giuriato, Luisa
core +1 more source