Results 121 to 130 of about 2,317,544 (334)
Molecular Oncology, EarlyView.Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li +12 more
wiley +1 more source
AgricultureThe early design parameters exert a considerable influence on the cooling energy demand of a granary building in operation. In order to investigate the impact of various parameters on energy use, a grain warehouse energy model was constructed using the ...
Hua Zhang +4 more
doaj +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Predictor Importance for Hydrological Fluxes of Global Hydrological and Land Surface Models
Water Resources ResearchGlobal Hydrological and Land Surface Models (GHM/LSMs) embody numerous interacting predictors and equations, complicating the understanding of primary hydrological relationships.
João Paulo L. F. Brêda +7 more
doaj +1 more source
High-Speed RailwayIn the field of rail transit, the UK Department of Transport stated that it will realize a comprehensive transformation of UK railways by 2050, abandoning traditional diesel trains and upgrading them to new environmentally friendly trains.
Yizhe Zhang +4 more
doaj +1 more source
Engineering Applications of Computational Fluid Mechanics, 2018 This paper presents a multi-objective optimization methodology that applies the Non-dominated Sorting Genetic Algorithm-II(NSGA-II) to propeller design, and realizes Fluid-Structure Interaction (FSI) weak-coupling based on Panel Method (PM) and the ...
Jingwei Jiang +5 more
doaj +1 more source
Globalisation, domestic inflation and global output gaps: Evidence from the euro area [PDF]
This paper tests whether the proposition that globalisation has led to greater sensitivity of domestic inflation to the global output gap (the “global output gap hypothesis”) holds for the euro area.
Calza, Alessandro
core
Decrypting cancer's spatial code: from single cells to tissue niches
Molecular Oncology, EarlyView.Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik +4 more
wiley +1 more source
BMC MedicineBackground Many European countries experienced outbreaks of mpox in 2022, and there was an mpox outbreak in 2023 in the Democratic Republic of Congo. There were many apparent differences between these outbreaks and previous outbreaks of mpox; the recent ...
Madhav Chaturvedi +6 more
doaj +1 more source
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source