Results 131 to 140 of about 2,317,544 (334)
Comparison of 30 day integrations with and without interactive clouds [PDF]
A cloud radiation interaction parameterization package has recently been incorporated into a global spectral General Circulation Model (GCM) used for extended range prediction studies at GFDL. The elements of this package are summarized.
Gordon, C. T.
core +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Discrepancy Measures for Global Sensitivity Analysis
TechnometricsWhile sensitivity analysis improves the transparency and reliability of mathematical models, its uptake by modelers is still scarce. This is partially explained by its technical requirements, which may be hard to understand and implement by the nonspecialist. Here we propose a sensitivity analysis approach based on the concept of discrepancy that is as
Arnald Puy +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.This real‐world study of ROS1+ NSCLC highlights fusion diversity, treatment outcomes with crizotinib and lorlatinib, and in vitro experiments with resistance mechanisms. G2032R drives strong resistance to ROS1‐targeted TKIs, especially lorlatinib. Fusion partner location does not affect overall survival to crizotinib or lorlatinib. Findings support the
Fenneke Zwierenga +8 more
wiley +1 more source
IEEE AccessVehicles are complex systems composed of interdependent subsystems, where a change in one component can propagate through others, causing knock-on effects and impacting the overall performance.
Sai Kausik Abburu +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Using multi‐omic characterization, we aimed to identify key regulators specific to squamous cell lung carcinoma (SqCC). SqCC‐specific differentially expressed genes were integrated with metabolics data. High expression of the creatine transporter SLC6A8, along with elevated creatine levels, appeared to be a distinct metabolic feature of SqCC.
Johan Staaf +10 more
wiley +1 more source
Global sensitivity analysis of parameters based on sPCE: The case study of a concrete face rockfill dam in northwest China. [PDF]
PLoS One, 2023 Ran L, Yang J, Ma C, Cheng L, Zhou M.
europepmc +1 more source
Molecular Oncology, EarlyView.This study highlights the potential of automated enumeration using the ACCEPT software to refine circulating tumor cell (CTC) detection in metastatic colorectal cancer (mCRC). The automated method demonstrates improved accuracy and reduced variability compared to the manual approach.
Michela De Meo +6 more
wiley +1 more source
A new paradigm for global sensitivity analysis
Current theory of global sensitivity analysis, based on a nonlinear functional ANOVA decomposition of the random output, is limited in scope-for instance, the analysis is limited to the output's variance and the inputs have to be mutually independent-and leads to sensitivity indices the interpretation of which is not fully clear, especially interaction
openaire +3 more sources
National economic policy simulations with global interdependencies : a sensitivity analysis for Germany [PDF]
"Policy simulations for national economies with econometric models in general are done using a stand alone national model with exogenous export values and import prices. In a globalised world such an exercise is critical, since the policy in question may
Lutz, Christian +3 more
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