Results 61 to 70 of about 782,077 (262)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Existence of local and global solutions to some impulsive fractional differential equation

Electronic Journal of Differential Equations, 2009
First, by using Schauder's fixed-point theorem we establish the existence uniqueness of locals for some fractional differential equation with a finite number of impulses.
Said Mazouzi, Rahima Atmania
doaj  

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Global attractor for a semilinear parabolic equation involving Grushin operator

Electronic Journal of Differential Equations, 2008
The aim of this paper is to prove the existence of a global attractor for a semilinear degenerate parabolic equation involving the Grushin operator.
Phan Quoc Hung, Tran Dinh Ke, Trinh Tuan Phong, Cung The Anh   +3 more
doaj  

Quarantine Order Violators System using Face Recognition (FACID)

Journal of Computing Research and Innovation
Face recognition technology is commonly utilized for user authentication and verification by analysing a digital image of a person's face and matching it against a database of faces for identification purposes. The COVID-19 pandemic has led to mandatory
Yamunnawahthi Somasundharam , Suraya Abu Bakar, Syifak Izhar Hisham   +2 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Existence and asymptotic behavior of global regular solutions for a 3-D Kazhikhov-Smagulov model with Korteweg stress

Electronic Journal of Differential Equations, 2016
In this article, we consider a 3-D multiphasic incompressible fluid model, called the Kazhikhov-Smagulov model, with a specific Korteweg stress tensor.
Meriem Ezzoug, Ezzeddine Zahrouni
doaj  

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Global existence and blow-up of solutions for parabolic systems with nonlinear nonlocal boundary conditions

Electronic Journal of Differential Equations, 2013
In this article we study a nonlinear parabolic system with nonlinear nonlocal boundary conditions. We prove the uniqueness of the solutions and establish the conditions for global solutions and non-global solutions.
Zhou Sen, Zuodong Yang
doaj