Results 81 to 90 of about 782,077 (262)

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

Boundedness and global solvability for a chemotaxis-haptotaxis model with p-Laplacian diffusion

open access: yesElectronic Journal of Differential Equations, 2020
We consider a chemotaxis-haptotaxis system with $p$-Laplacian diffusion in three dimensional bounded domains. It is asserted that for any p>2, under the appropriate assumptions, the chemotaxis-haptotaxis system admits a global bounded weak ...
Changchun Liu, Pingping Li
doaj  

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

open access: yesMolecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj   +4 more
wiley   +1 more source

Existence of global solutions for a predator-prey model with cross-diffusion

open access: yesElectronic Journal of Differential Equations, 2008
In this article, we prove the existence of global classical solutions for a prey-predator model when the space dimension ...
Shenghu Xu
doaj  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Existence of global solutions for systems of second-order differential equations with p-Laplacian

open access: yesElectronic Journal of Differential Equations, 2007
We obtain sufficient conditions for the existence of global solutions for the systems of differential equations $$ ig(A(t)Phi_p(y')ig)' + B(t)g(y') + R(t)f(y) = e(t), $$ where $Phi_p(y')$ is the multidimensional p-Laplacian.
Eva Pekarkova, Milan Medved
doaj  

Towards the Prediction of Global Solution State Properties for Hydrogen Bonded, Self-Associating Amphiphiles. [PDF]

open access: yesChemistry, 2018
White LJ   +7 more
europepmc   +1 more source

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