Results 111 to 120 of about 2,378,174 (337)

Analysis of a model for the effects of an external toxin on anaerobic digestion

open access: yesMathematical Biosciences and Engineering, 2012
Anaerobic digestion has been modeled as a two-stage process using coupled chemostat models with non-monotone growth functions, [9]. This study incorporates the effects of an external toxin.
Marion Weedermann
doaj   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

EGFR‐STAT3 activation provides a therapeutic rationale for targeting aggressive ETV1‐positive prostate cancer

open access: yesMolecular Oncology, EarlyView.
Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva   +5 more
wiley   +1 more source

Global Stability and Plus-Global Stability. An Application to Forward Neural Networks

open access: yes, 2010
A necessary and sufficient condition for a discrete dynamical system to be globally stable and plus-globally stable are first established in Section 2. The V-condition is introduced and Theorems 3.5 and 3.7 are presented in Section 3. The two theorems link the V-condition to the most relevant properties of globally stable and plus-globally stable ...
G. Di Lena   +2 more
openaire   +2 more sources

The Global Stability of Walrasian Tâtonnement

open access: yesApplied Mathematics Letters, 1991
AbstractThe main result herein is that the Walrasian tâtonnement process for a class of economics that generalizes those studied by Scarf and Hirota is globally stable if and only if the usual boundary conditions are satisfied.
Robert H. Oehmke, James F. Oehmke
openaire   +2 more sources

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee   +9 more
wiley   +1 more source

Role Reversals in a Tri-Trophic Prey–Predator Interaction System: A Model-Based Study Using Deterministic and Stochastic Approaches

open access: yesMathematical and Computational Applications
It is frequently observed that adult members of prey species sometimes use their predation mechanism on juvenile members of predator species. Ecological literature describes this phenomenon as prey–predator role reversal dynamics.Numerous authors have ...
Sk Golam Mortoja   +4 more
doaj   +1 more source

Raphin‐1 mediates the survival and sensitivity to radiation of pediatric‐type diffuse high‐grade glioma via phosphorylated eukaryotic initiation factor 2α‐dependent and ‐independent processes

open access: yesMolecular Oncology, EarlyView.
Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan   +4 more
wiley   +1 more source

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