Results 41 to 50 of about 716,482 (227)

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

open access: yesMolecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop   +10 more
wiley   +1 more source

La questione morale dei cambiamenti climatici [PDF]

open access: yesS&F_scienzaefilosofia.it, 2012
Though a chorus of voices has risen to deny the alarm about climate changes during last years, the great majority of the scientific community believe that without further commitment and action to reduce greenhouse gas emissions, due to human activities ...
Caserini, Stefano
doaj  

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

open access: yesMolecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed   +8 more
wiley   +1 more source

GLOBAL WARMING: A Critical View

open access: yesRevista Brasileira de Climatologia, 2008
In the last 150 years, the mean global temperature rose about 0,7°C. Thisincrease is being attributed to the enhancement of the greenhouse effect dueanthropic activities, such as fossil fuel and tropical forest burning, that emit CO2– a greenhouse gas ...
Luiz Carlos Baldicero Molion
doaj   +1 more source

Present global warming: a justifiable and stable metric for evaluating short-lived climate pollutants

open access: yesEnvironmental Research Letters, 2022
The impacts of short-lived climate pollutants (SLCPs) such as methane are typically described using metrics that compare their climate impacts to carbon dioxide’s climate impact.
Andrew E Pomerantz, Robert L Kleinberg
doaj   +1 more source

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner   +6 more
wiley   +1 more source

Global Warming and Health

open access: yesRGUHS Journal of Medical Sciences
Human activities are associated with deforestation and the burning of fossil fuels. There is an anthropogenic emission of greenhouse gases resulting in global warming.
P S Shankar
doaj   +1 more source

Australian climate warming: observed change from 1850 and global temperature targets [PDF]

open access: yesJournal of Southern Hemisphere Earth Systems Science, 2023
Mean annual temperature is often used as a benchmark for monitoring climate change and as an indicator of its potential impacts. The Paris Agreement of 2015 aims to keep the global average temperature well below 2°C above pre-industrial levels, with a ...
Edward Hawkins   +7 more
doaj  

Mechanisms affecting the overturning response in global warming simulations [PDF]

open access: yes, 2005
Climate models used to produce global warming scenarios exhibit widely diverging responses of the thermohaline circulation (THC). To investigate the mechanisms responsible for this variability, a regional Atlantic Ocean model driven with forcing ...
Schweckendiek, Ulf, Willebrand, Jürgen
core   +1 more source

EGFR‐STAT3 activation provides a therapeutic rationale for targeting aggressive ETV1‐positive prostate cancer

open access: yesMolecular Oncology, EarlyView.
Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva   +5 more
wiley   +1 more source

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