Results 51 to 60 of about 114,745 (261)
Environmental Research Letters, 2022 The impacts of short-lived climate pollutants (SLCPs) such as methane are typically described using metrics that compare their climate impacts to carbon dioxide’s climate impact.
Andrew E Pomerantz, Robert L Kleinberg
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Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
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, 2010 Tracing scientific ideas about the structure of Earth, Global Warming creates an intellectual portrait of the shifts in thinking that have led to the current controversy, enabling readers to make up their own minds on this important issue. Global Warming takes one of the hot-button issues of our time and surveys it in historical context, creating ...
Brian C. Black, Gary J. Weisel
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Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Global warming: preventing irreversibility
Brazilian Journal of Political EconomyThe United Nations Framework Convention on Climate Change met again in Bonn for the COP23 in the fall with Fiji as host, the focus should have been upon the GOAL II in the COP21 Treaty: decarbonisation with 30-40 per cent of 2005 levels until 2030 ...
JAN-ERIK LANE
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Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
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The discovery of global warming
Revista Brasileira de História da Ciência, 2008 Em uma cuidadosa e brilhante narrativa, Spencer R. Weart, físico de formação e um notório historiador de ciências, diretor do Centro de Historia da Física do Instituto Americano de Física, autor de numerosos artigos históricos e de livros conceituados ...
Mario Ferreira
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Australian climate warming: observed change from 1850 and global temperature targets [PDF]
Journal of Southern Hemisphere Earth Systems Science, 2023 Mean annual temperature is often used as a benchmark for monitoring climate change and as an indicator of its potential impacts. The Paris Agreement of 2015 aims to keep the global average temperature well below 2°C above pre-industrial levels, with a ...
Edward Hawkins +7 more
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Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source