Results 51 to 60 of about 739,711 (300)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, Volume 20, Issue 6, Page 1494-1512, June 2026.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Global Warming and Health

RGUHS Journal of Medical Sciences
Human activities are associated with deforestation and the burning of fossil fuels. There is an anthropogenic emission of greenhouse gases resulting in global warming.
P S Shankar
doaj   +1 more source

La questione morale dei cambiamenti climatici [PDF]

S&F_scienzaefilosofia.it, 2012
Though a chorus of voices has risen to deny the alarm about climate changes during last years, the great majority of the scientific community believe that without further commitment and action to reduce greenhouse gas emissions, due to human activities ...
Caserini, Stefano
doaj  

Public Perception of Climate Change and the New Climate Dice

, 2012
"Climate dice", describing the chance of unusually warm or cool seasons relative to climatology, have become progressively "loaded" in the past 30 years, coincident with rapid global warming.
Hansen, James, Ruedy, Reto, Sato, Makiko
core   +1 more source

Global Warming, Global Warming Pause and the Role of CO2 [PDF]

Proceedings of Accretion Processes in Cosmic Sources — PoS(APCS2016), 2018
We discuss several aspects of the phenomenon called Global Warming and refrain from any con- clusions. We leave the reader to draw his conclusions about the series of observations presented here. The phenomenon called Global Warming or in the new name Climate Change, refers to the be- havior of the ’Temperature of the Earth’ as a function of time. The
openaire   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, Volume 20, Issue 6, Page 1643-1660, June 2026.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Global warming: preventing irreversibility

Brazilian Journal of Political Economy
The United Nations Framework Convention on Climate Change met again in Bonn for the COP23 in the fall with Fiji as host, the focus should have been upon the GOAL II in the COP21 Treaty: decarbonisation with 30-40 per cent of 2005 levels until 2030 ...
JAN-ERIK LANE
doaj   +1 more source

The discovery of global warming

Revista Brasileira de História da Ciência, 2008
Em uma cuidadosa e brilhante narrativa, Spencer R. Weart, físico de formação e um notório historiador de ciências, diretor do Centro de Historia da Física do Instituto Americano de Física, autor de numerosos artigos históricos e de livros conceituados ...
Mario Ferreira
doaj   +1 more source