Results 71 to 80 of about 114,745 (261)
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Q&A: Global warming: No easy answers
California Agriculture, 2000 California Agriculture - All ...
F Rowland
doaj
Environmental Research LettersUneven economic impacts of climate change have been largely caused by differentiated warming rates across different geographical regions, affecting the lives of the majority of world’s population. Historical and future warming rates are commonly obtained
Yilin Meng, Yan Yu, Ji Nie
doaj +1 more source
Asymmetric Response to Global Warming
Journal of Education, Health and SportThe study aims to develop critical thinking in the context of global warming, analyze existing approaches to solving this problem, and propose alternative methods of combating climate change. Materials and methods: Scientific literature was analyzed,
Anatoliy Zhukov, Walery Zukow
doaj +1 more source
FEBS Open Bio, EarlyView.This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia +3 more
wiley +1 more source
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
Climate extremes in Europe at 1.5 and 2 degrees of global warming
Environmental Research Letters, 2017 There is an international effort to attempt to limit global warming to 1.5 °C above pre-industrial levels, however, there is a lack of quantitative analysis on the benefits of holding global warming to such a level.
Andrew D King, David J Karoly
doaj +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Environmental Research LettersSince the beginning of 21st century, mesoscale convective systems (MCSs) precipitation in the Yangtze River Basin (YRB) has increased by approximately 25% per decade. Given the concurrent global warming, it is crucial to distinguish the relative roles of
Zhongxi Lin +4 more
doaj +1 more source