Results 71 to 80 of about 5,140,187 (303)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Global Warming Countermeasures : Current Situation and Future Prospects [PDF]

open access: yes, 2007
The world is currently under threat of destruction. The Arctic ice is melting, and abnormal weather conditions such as severe droughts and hurricanes have been reported around the world.
タカノ, ヒロキ   +2 more
core  

Global Warming and long term fluctuation of temperature. [PDF]

open access: yes, 2008
Global Warming is a major concern for all the people in the world. To stop the increase of the temperature, it is necessary to reduce carbon dioxide emissions.
桂, 重樹   +2 more
core   +1 more source

Global warming: preventing irreversibility

open access: yesBrazilian Journal of Political Economy
The United Nations Framework Convention on Climate Change met again in Bonn for the COP23 in the fall with Fiji as host, the focus should have been upon the GOAL II in the COP21 Treaty: decarbonisation with 30-40 per cent of 2005 levels until 2030 ...
JAN-ERIK LANE
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Oregon Global Warming Commission roadmap to 2020: phase 1 summary report

open access: yes, 2011
This archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Title from PDF caption (viewed on Oct.

core  

Cloudy Skies: Assessing Public Understanding of Global Warming

open access: yes, 2002
Surveys show most Americans believe global warming is real. But many advocate delaying action until there is more evidence that warming is harmful.
John D. Sterman   +3 more
core   +1 more source

Scaled biotic disruption during early Eocene global warming events [PDF]

open access: yes, 2012
Late Paleocene and early Eocene hyperthermals are transient warming events associated with massive perturbations of the global carbon cycle, and are considered partial analogues for current anthropogenic climate change.
Murphy, B.H.   +33 more
core   +3 more sources

The discovery of global warming

open access: yesRevista Brasileira de História da Ciência, 2008
Em uma cuidadosa e brilhante narrativa, Spencer R. Weart, físico de formação e um notório historiador de ciências, diretor do Centro de Historia da Física do Instituto Americano de Física, autor de numerosos artigos históricos e de livros conceituados ...
Mario Ferreira
doaj   +1 more source

Australian climate warming: observed change from 1850 and global temperature targets [PDF]

open access: yesJournal of Southern Hemisphere Earth Systems Science, 2023
Mean annual temperature is often used as a benchmark for monitoring climate change and as an indicator of its potential impacts. The Paris Agreement of 2015 aims to keep the global average temperature well below 2°C above pre-industrial levels, with a ...
Edward Hawkins   +7 more
doaj  

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