Results 71 to 80 of about 739,711 (300)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

The ABCs of Global Warming [PDF]

open access: yes
This essay provides a broad methodological framework for thinking about what is needed policy-wise for addressing climate change due to increased carbon emissions.
Robert Shelburne
core  

Environmental Superstatistics

open access: yes, 2013
A thermodynamic device placed outdoors, or a local ecosystem, is subject to a variety of different temperatures given by short-tem (daily) and long-term (seasonal) variations.
Beck, Christian, Yalcin, G. Cigdem
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Asymmetric Response to Global Warming

open access: yesJournal of Education, Health and Sport
The study aims to develop critical thinking in the context of global warming, analyze existing approaches to solving this problem, and propose alternative methods of combating climate change. Materials and methods: Scientific literature was analyzed,
Anatoliy Zhukov, Walery Zukow
doaj   +1 more source

Global warming and water sustainability

open access: yesE3S Web of Conferences, 2014
Water is a primary element in the human diet and a necessary resource for the agriculture. In addition, industrial practices need a growing amount of water.
Cassardo Claudio
doaj   +1 more source

The Semiotics of Global Warming: Combating Semiotic Corrruption [PDF]

open access: yes, 2007
The central focus of this paper is the disjunction between the findings of climate science in revealing the threat of global warming and the failure to act appropriately to these warnings. The development of climate science can be illuminated through the
Gare, Arran
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Uncertainty and global warming : an option - pricing approach to policy [PDF]

open access: yes
Uncertainty is inherent in the analysis of global warming issues. Not only is there considerable scientific uncertainty about the magnitude of global warming, but even if that problem were resolved, there is uncertainty about what monetary value to ...
Baranzini, Andrea   +2 more
core  

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