Results 81 to 90 of about 5,140,187 (303)
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
, 2008 Program One: The Science of Global Warming We cannot predict the consequences of Global Warming without clearly understanding the "how" and "why" Global Warming is occurring.
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Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Global Warming and the Game Theory
, 2016 With the increase in carbon dioxide, there are a number of international initiatives to combat global warming. However, the cooperation cannot be described as adequate.
Shimamoto, Kenichi +5 more
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The rogue nature of hiatuses in a global warming climate
Geophysical Research Letters, 2016 The nature of rogue events is their unlikelihood and the recent unpredicted decade‐long slowdown in surface warming, the so‐called hiatus, may be such an event.
F. Sévellec, B. Sinha, N. Skliris
doaj +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Global warming policy: some economic implications [PDF]
Many analysts believe that the emissions of greenhouse gases resulting from human activity are contributing to global warming, but the linkage is highly uncertain.
Stephen P. A. Brown
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Molecular Oncology, EarlyView.Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler +3 more
wiley +1 more source
The Select Committee on Energy Independence & Global Warming
, 2011 Website for the United States Select Committee on Energy Independence and Global Warming including information about the Committee, hearings and publicattions, and other resources related to research into managing the effects of petroleum reliance and ...
United States. Congress. House. Select Committee on Energy Independence and Global Warming.
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Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source